复方稳斑汤联合增强型体外反搏治疗冠心病的临床疗效及对血栓素A2的影响

摘要

Objective To observe the clinical curative effect of Fufang Wenban decoction (FWD)and enhanced external counterpul-sation (EECP)for treatment of coronary heart disease (CHD)unstable angina pectoris (UAP)and its influence on serum thrombox-ane A2 (TXA2 )levels.Methods One hundred and twenty patients with UAP were randomly divided into two groups:control group(n=60)treated with routine treatment,treatment group(n=60)treated withroutine treatment routine treatment and FWD plus EECP for 4 weeks.The angina symptoms integral,angina pectoris curative effect and TCM syndrome integral,TCM syndrome curative effect and serum TAX2 levels were observed.Results After treatment,angina symptoms integral,TCM syndrome integral were decreased sig-nificantly in two groups,which was significantly lower in treatment group than that in control group(P<0.05).The significant efficien-cy of angina symptoms and TCM syndrome in treatment group were significantly higher than that in control group(P<0.05).The lev-els of serum TXA2 were decreased significantly in two groups,which was significantly lower in treatment group than that in control group(P<0.05).Conclusion FWD and EECP is obviously effective for UAP.It may be one of its mechanisms by blocking the syn-thesis of TXA2 in platelets and inhibiting platelet aggregation.%目的：观察复方稳斑汤联合增强型体外反搏(EECP)治疗冠心病不稳定型心绞痛(痰瘀互结证)的临床疗效及对血栓素A2(TXA2)含量的影响。方法将符合纳入标准的120例冠心病不稳定型心绞痛病人随机分为治疗组(60例)和对照组(60例)。治疗组采用中药复方稳斑汤、西医基础治疗加体外反搏治疗，对照组采用西医基础治疗。两组疗程为4周。比较两组受试者心绞痛症状积分、心绞痛症状疗效、中医证候积分、中医证候疗效、TXA2的含量。结果治疗后治疗组和对照组心绞痛症状积分、中医证候积分均有显著降低(P<0.05)，治疗组显著低于对照组(P<0.05)；治疗组心绞痛症状显效率、中医证候显效率显著高于对照组(P<0.05)；治疗组和对照组血栓素 A2含量均显著降低(P<0.05)，治疗组显著高于对照组(P<0.05)。结论复方稳斑汤联合 EECP疗法能够更有效地治疗冠心病不稳定型心绞痛，阻断 TXA2在血小板中的合成，抑制血小板聚集可能是其作用机制之一。