目的 观察复方稳斑汤联合体外反搏治疗对冠心痛不稳定型心绞痛病人的临床疗效及其对血清一氧化氮(NO)和血管内皮素-1(ET-1)水平的影响.方法 收集120例确诊冠心病不稳定型心绞痛病人,随机分为两组,对照组(60例)和试验组(60例).对照组采用复方稳斑汤加常规西药治疗;试验组在对照组基础上联合体外反搏治疗,治疗时间均为4周,比较两组心绞痛症状、中医证候、NO及ET-1等指标.结果 治疗后试验组的心绞痛症状疗效、中医证候疗效均显著优于对照组(P＜0.05).治疗后两组中医证候积分均显著下降(P＜0.05),且试验组优于对照组(P＜0.05).治疗后试验组和对照组NO及ET-1均有显著改善,且试验组优于对照组(P＜0.05).结论 复方稳斑汤联合体外反搏治疗可以改善冠心病不稳定型心绞痛病人的心绞痛症状及中医证候,调节NO及ET-1水平.%Objective To observe the effects of compound Wenban decoction (CWD) and enhanced external counterpulsation (EECP) on the levels of serum nitric oxide (NO) and endothelin-1 (ET-1) in patients:with unstable angina pectoris (UAP).Methods One hundred and twenty patients with UAP were collected and randomly divided into two groups:control group (n =60) treated with routine treatment plus CWD,and treatment group (n =60) treated with routine treatment plus CWD and EECP for 4 weeks.The changes of angina pectoris symptoms,Chinese medical syndrome and the levels of serum NO and ET-1 were observed.Results After treatment,the curative effects of angina pectoris symptom,and Chinese medical syndrome in treatment group were obviously better than that in control group (P ＜0.05).The scores of Chinese medical syndrome declined obviously in two groups,which was obviously better in treatment group than that in control group (P ＜0.05).After treatment,the levels of serum NO and ET-1 improved obviously in two groups,which was obviously better in treatment group than that in control group (P ＜0.05).Conclusion CWD and EECP can improve the symptoms of angina pectoris and Chinese medical syndrome in patients with UAP and regulate the levels of serum NO and ET-1.
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