老年糖尿病心血管病变中医证型、舌象与超敏C反应蛋白、晚期糖基化终产物的关系研究

摘要

Objective To investigate the relationship between traditional Chinese medicine (TCM) syndrome,tongue appearance and high-sensitivity C-reactive protein (hs-CRP),advanced glycation end products (AGEs) in elderly patients with diabetic cardiovascular disease.Methods Eighty-nine patients with diabetic cardiovascular disease were enrolled.The TCM syndrome,tongue appearance were observed.The levels of hs-CRP,AGEs were observed.Results The main TCM syndrome was phlegm retained in heart vessels,followed by qi deficiency and blood stasis syndrome.The levels of UA/Cr,AGEs and hs-CRP were significantly higher in phlegm retained in heart vessels group and qi deficiency and blood stasis syndrome group than that in various other syndromes group (P ＜0.05).The main tongue body was dark red tongue,followed by purple tongue.The levels of UA/Cr,AGEs and hs-CRP were significantly higher in dark red tongue group and purple tongue group than that in various other tongue body group (P ＜0.05).The main tongue coating was white thick fur,followed by yellow thick fur.The levels of UA/Cr,AGEs and hs-CRP were significantly higher in white thick fur group and thick yellow fur group than that in various other tongue coating group (P ＜0.05).Correlation analysis showed that TCM syndromes,tongue body and coating were positively correlated with AGEs and hs-CRP levels.Conclusion The main TCM syndrome were phlegm retained in heart vessels,qi deficiency and blood stasis syndrome,the main tongue body were dark red tongue and purple tongue,and the main tongue coating were white thick fur and yellow thick fur in elderly patients with diabetic cardiovascular disease.TCM syndrome,tongue and hs-CRP,AGEs were positively correlated.%目的 探讨老年糖尿病心血管病变中医证型、舌象与超敏C反应蛋白(hs-CRP)、晚期糖基化终产物(AGEs)的关系.方法 对89例老年糖尿病心血管病变病人根据不同的中医证型、舌象,分析血清中超敏C反应蛋白、晚期糖基化终末产物的变化,探讨证型、舌象与hs-CRP、AGEs的关系.结果 89例老年糖尿病心血管病变病人中以痰阻心脉证最多,气虚血瘀证次之,痰阻心脉证组、气虚血瘀证组尿酸(UA)/肌酐(Cr)、AGEs及hs-CRP显著高于其他各证型组(P＜0.05);舌质分布中以暗红舌最多,其次为青紫舌.青紫舌、暗红舌组UA/Cr、AGEs及hs-CRP显著高于其他各舌质组(P＜0.05);舌苔分布中以白厚苔最多,其次为黄厚苔,白厚苔、黄厚苔组UA/Cr、AGEs及hs-CRP显著高于其他各舌苔组(P＜0.05);相关性分析显示,中医证型、舌质、舌苔均与AGEs及hs-CRP呈正相关.结论 老年糖尿病心血管病的中医证型多以痰阻心脉证、气虚血瘀证为主,舌质以暗红舌、青紫舌、舌苔多以白厚苔、黄厚苔为主,且证型、舌象均与hs-CRP、AGEs呈正相关.