Cardiovascular status is one of the strongest predictors of both cardiovascular diseases death and all-cause death.Exercise training (ET) has been proved to be an effective and economical strategy to overcome the cardiovascular deleterious effects.microRNAs (miRNAs or miRs) are a class of small,noncoding RNAs which regulate gene expression at post-transcriptional level.Current studies have revealed that many miRNAs induce the protective effects of ET by regulating structures and functions of heart and blood vessel.For example,miR-1,miR-214,miR-19b,miR-30e,miR 29,miR-455,miR-30c,and miR-222 are involved in ET-related heart protection,miR-146a,miR-30e,miR-23b,miR-130a,miR-16,miR-21,miR 24,miR 92a,miR-126,miR-143/145,miR-155,and miR 221/222 take park in ET-related vessel protection.What is more,besides ET,many other intervention strategies can also regulate miRNAs level.So,it is obviously that miRNAs underline a new protective mechanism for cardiovascular health,and ET should be used as a special drug in medical practice.%血液循环系统健康是心血管疾病和全因死亡率的强有力预测因素,适当的运动康复是防治心血管疾病有效和经济措施之一.MicroRNAs(miRNAs、miRs)是一类内源性非编码RNA,可在转录后水平调控基因表达.目前研究显示miR-1、miR 214、miR-19b、miR-30e、miR-29、miR-455、miR-30c、miR-222等介导运动对心脏的保护作用,miR-146a、miR-30e、miR-23b、miR-130a、miR 16、miR-21、miR-24、miR-92a、miR-126、miR-143/145、miR-155、miR-221/222等介导运动对血管的保护作用.miRNA介导运动保护心血管的作用主要表现为以下3个特点:心血管运动康复与miRNA相关、运动方式不同miRNA表达不同、miRNA是心血管运动康复与其他多种干预措施的共同靶点.以上结果提示miRNAs是心血管运动康复的重要作用机制,也是其他多种干预措施的靶点,提示心血管运动康复可以作为治疗处方应用于临床.
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