Objective The aim of study is to observe the effect of Shenma Yizhi decoction (SYD) on hemorheology and cognitive function in mild and moderate vascular dementia (VD).Methods Sixty patients were randomly divided into two groups:control group (n =30) treated with routine treatment plus ginkgo leaves tablets,and experimental group (n =30) treated with SYD in the basis of routine treatment for 3 months.The Mini-mental State Examination (MMSE) score and the hemorheological indexes were observed and compared.Results The MMSE scores of the experimental group and the control group was significantly improved in two groups after treatment (P ＜0.05),while was better in experimental group than that in control group (P ＜0.05).In the detection of hemotheological index:When the shear rate were 1.0 s-1 and 5.0 s-1,the blood viscosity of the two groups was significantly lower than that before treatment(P ＜0.05),and there was no significant difference between the two groups after treatment (P ＞ 0.05).When the shear rate were 10.0 s-1,35.0 s-1,120.0 s-1,the blood viscosity had no significant difference in experimental group (P ＞0.05),while it was significantly lower than that before treatment in control group(P ＜0.05).After treatment,the erythrocyte deformation index was significantly higher than that before treatment in experimental group (P ＜0.05),while the control group had no significant difference (P ＞0.05).The platelet aggregation rate and adhesion rate of the two groups were significantly lower than those before treatment (P ＜0.05),and there was no significant difference between the two groups after treatment (P ＞0.05).Conclusion SYD can improve the cognitive dysfunction in patients with mild and moderate VD.Meanwhile,it can increase erythrocyte deformability,inhibit platelet function,reduce blood viscosity and improve the blood rheology.%目的 观察参麻益智方对轻中度血管性痴呆(VD)病人认知功能及血液流变学的影响.方法 社区筛选60例轻中度VD病人,随机分为试验组和对照组,各30例,在常规治疗基础上,试验组给予参麻益智颗粒剂,对照组给予银杏叶片,疗程3个月.治疗前后分别行简易智能状态量表(MMSE)评分,并进行血液黏度(椎-板法)、红细胞功能和血小板功能等流变学指标的检测.结果 两组治疗后MMSE评分与治疗前比较差异有统计学意义(P＜0.05),且试验组改善程度优于对照组(P＜0.05).与治疗前比较,两组治疗后剪切率为1.0 s-1、5.0 s-1时血液黏度降低,差异有统计学意义(P＜0.05);组间治疗后比较,两组剪切率为1.0 s-1时血液黏度差异有统计学意义(P＜0.05);两组剪切率为5.0 s-1时血液黏度差异无统计学意义(P＞0.05).试验组治疗后剪切率为10.0s-1、35.0 s-1、120.0 s-1时血液黏度与治疗前比较,差异无统计学意义(P＞0.05),对照组治疗后剪切率为10.0 s-1、35.0 s-1、120.0 s-1时血液黏度与治疗前比较,差异有统计学意义(P＜0.05).试验组治疗后红细胞变形能力较治疗前显著升高,差异有统计学意义(P＜0.05);两组治疗后血小板聚集率和黏附率与治疗前比较差异有统计学意义(P＜0.05),两组组间比较差异无统计学意义(P＞0.05).结论 参麻益智方能有效改善轻中度VD病人的认知功能障碍,并能提高病人的红细胞变形能力、抑制血小板的聚集和黏附性、降低血液黏度,改善病人血液的流变性.
展开▼
