围绝经期高血压患者红细胞体积分布宽度变异系数的观察

摘要

目的 观察围绝经期高血压患者红细胞体积分布宽度(RDW )变异系数(CV )的变化,为围绝经期高血压的预防与治疗提供新的思路.方法 采用病例对照研究的方法,回顾性分析55 例围绝经期高血压患者(围绝经期高血压组)的临床资料,以同期56 例健康者为健康对照组,再按高血压分级的不同将围绝经期高血压组分为高血压1 级组(36 例)和高血压2 级组(19 例).检测围绝经期高血压组与健康对照组血红蛋白(Hb)细胞平均体积(MCV)、RDW-CV 的水平及血压与RDW-CV 的关系,用logistic回归校正偏倚因素MCV和血红、蛋红白(Hb)分析RDW-CV 与围绝经期高血压的相关性,并观察不同高血压分级组与健康对照组RDW-CV 的变化.结果 围绝,经期高血压组患者Hb(g/L)、MCV(fl )均较健康对照组明显降低(Hb:143.14±12.18 比157.36±13.31,MCV:86.13±5.13 比91.31±6.51,均P＜0.05)RDW-CV 明显升高[(14.13±1.08)% 比(12.35±0.83)%,P＜0.05 ],校正MCV 和Hb 等偏倚因素后,RDW-CV 与,围绝经期高血压有相关性[Hb:优势比(OR)=0.618,MCV:OR = 0.753,RDW-CV:OR = 0.761,均P＜0.05 ]高血压不同分级组患者的RDW-CV 均较健康对照组明显升高,以高血压2 级组升高更显著[(14.26±0.89)%比,(12.35±0.82)%,P＜0.05 ].结论 RDW-CV 与围绝经期高血压存在独立的相关性,提示RDW-CV 可能成为围绝经期高血压患者的一个临床监测指标,为该患者群提供心脑血管危象的预警信息.%Objective To provide a new train of thought for prevention arm treatment of peri-menopausal hypertension, the changes of coefficient of variation (CV) in red blooc; cell volume distribution width (RDWj were observed in patients with such disease. Methods The clinical data of 55 patients with peri-menopausalrnand 56 healthy cases were selected in the same period as a healthy control group. The peri-menopausal hypertension group was subdivided into hypertension grade 1 and 2 groups according to the grace classification of hypertension. The levels of hemoglobin (Hb), mean corpuscular volume (MCV) and RDW-CV were detected in peri-menopausal hypertension group and healthy control group, and the relationship between blood pressure and RDW-CV was analyzed. Logistic regression analysis was applied and the bias factors of MCV and Hb were calibrated ; afterwards the correlation between RDW-CV and peri-menopausal hypertension was analyzed. The changes of RDW-CV in hypertension grade 1 and 2 groups arm the healthy control group were observed. Results The levels of Hb (g/Lj and MCV (fl) were significantly lower (Hb ; 143.14+12.18 vs. 157.36nl3.31, MCV : 86.13.r5.13 vs. 91.31±6.51, both P＜0.05)in peri-menopausal hypertension group than those in healthy control group , while RDW-CV was obviously higher [(14.13±1.08) % vs. (12.35±0.83)%, P＜0.05] in the peri-menopausal hypertension than that in healthy control group. After correction of the bias factors of MCV and Hb, the result showed that RDW-CV had a positive correlation with peri-menopausal hypertension [ Hb ; odds ratio (OR) =0.618, MCV ; OR= 0.753, RDW-CV ; OR=0.761, all p＜0.05]. Compared with healthy control group, all peri-menopausal patients with hypertension had a significant increase in RDW-CV, the range of RDW-CV elevation in hypertension grade 2 group being more significant [ (14.26±0.89) % vs. (12.35±0.82) %, P＜0.05]. Conclusions RDW-CV independently correlates with peri-menopausal hypertension, therefore, RDW-CV can be a clinical monitoring indicator to provide an early information warning the peri-menopausal patients with hypertension the possible occurrence of cardiovascular and/or cerebrovas-cular crisis.