醒智益脑颗粒联合高压氧治疗对一氧化碳中毒迟发性脑病患者认知和运动功能的影响

摘要

Objective To investigate the therapeutic effects of Xingzhi Yinao (XZYN) particles combined with hyperbaric oxygen therapy on cognitive impairment and motor dysfunction in patients with delayed encephalopathy after acute carbon monoxide poisoning (DEACMP). Methods Sixty-seven patients with DEACMP were admitted to the Affiliated Yantai Yuhuangding Hospital of Qingdao University from January 2011 to December 2015, and they were randomly divided into a control group (given conventional treatment such as inhalation of oxygen, cytidine diphosphate cholin and vitamin B, 19 cases), a hyperbaric oxygen (HBO) treatment group (given conventional treatment + hyperbaric oxygen therapy once a day, 24 cases) and a XZYN particles treatment (XZYN group, given conventional treatment, hyperbaric oxygen and XZYN particles, 24 cases), the therapeutic course being 2 months in the three groups. Before and after treatment for 1 and 2 months, the cognitive function and motor function of the patients were evaluated by the use of activity of daily living (ADL) scale, Montreal cognitive assessment (MoCA) scale, and mini-mental state examination (MMSE) scale; the severity of cerebral white matter injury was assessed by age related white matter changes (ARWMC) scale; and the electromyographic evoked potential was used to detect the amplitude and latency of P300 to assess the severity of cognition impairment and prognosis. Results With the prolongation of therapeutic time, after treatment, the neurological function scores of ADL, MoCA, MMSE and amplitude of P300 were increased, while ARWMC was decreased and the latency of P300 was shortened gradually in the three groups, and the changes of above indexes after treatment for 2 months in XZYN group were more significant than those in either HBO group or control group[ADL score: 70.2±8.3 vs. 60.5±8.1, 23.0±6.1, MoCA score: 26.1±3.1 vs. 22.2±2.7, 18.2±3.6, MMSE score:25.9±4.1 vs. 22.4±3.5, 18.1±4.5, ARWMC score: 7.0±2.1 vs. 8.7±2.2, 15.2±3.3, latency of P300 (ms):332.9±20.4 vs. 352.5±23.6, 381.7±30.3, amplitude of P300 (μV): 6.5±1.6 vs. 5.6±1.3, 4.1±1.5, all P < 0.05]. Conclusion The hyperbaric oxygen therapy combined with XZYN particles for treatment of patients with DEACMP can significantly improve their cognitive and motor functions and ameliorate the severity of cerebral white matter injury.%目的 探讨醒智益脑颗粒联合高压氧治疗对一氧化碳中毒迟发性脑病(DEACMP)患者认知缺陷及运动功能障碍的影响.方法 选择青岛大学附属烟台毓璜顶医院2011年1月至2015年12月收治的67例DEACMP患者,常规治疗对照组(给予吸氧+胞二磷胆碱+ B族维生素)19例、高压氧治疗组(HBO组,在常规治疗基础上给予高压氧治疗,每日1次)24例和醒智益脑颗粒治疗组(XZYN组,给予常规治疗+高压氧+醒智益脑免煎颗粒治疗,共2个月)24例.于治疗前、治疗后1个月和2个月用日常生活能力(ADL)量表、蒙特利尔认知评估量表(MoCA)、简易智能精神状态检查量表(MMSE)评价患者的认知功能和运动功能;采用年龄相关性脑白质改变(ARWMC)量表评价患者的脑白质损伤程度;采用肌电图诱发电位仪检测P300波幅和潜伏期判断患者的认知损害严重程度以及预后.结果 随时间延长,3组治疗后ADL、MoCA、MMSE及P300波幅均逐渐升高,ARWMC均逐渐降低,P300潜伏期逐渐缩短,且上述指标以XZYN组治疗后2个月的变化较HBO组和对照组更显著〔ADL评分(分):70.2±8.3比60.5±8.1、23.0±6.1,MoCA评分(分):26.1±3.1比22.2±2.7、18.2±3.6,MMSE评分(分):25.9±4.1比22.4±3.5、18.1±4.5,ARWMC(分):7.0±2.1比8.7±2.2、15.2±3.3,P300潜伏期(ms):332.9±20.4比352.5±23.6、381.7±30.3,P300波幅(μV):6.5±1.6比5.6±1.3、4.1±1.5,均P<0.05〕.结论 醒智益脑颗粒联合高压氧治疗能明显改善DEACMP患者的认知及运动功能,减轻脑白质损伤程度.