滋肾调周法对反复体外受精-胚胎移植失败者卵巢反应性的影响

摘要

Objective To observe the ovarian response of repeated implantation failure (RIF) by the treatment ofZishen Tiaozhou.Methods Totally 70 patients with RIF were randomly divided into treatment group and blank control group averagely through random number table method. Treatment group was givenWenshen Yangxue Granule from the 5th day of the menstrual cycle andPeiyu Granule from the 10th day of the menstrual cycle, for successive 15 days. Three months was a treatment course. TCM syndrome score, FSH and LH in serum, uterine and ovarian volume, antral follicle count (AFC) before and after treatment, and clinical pregnancy rate into the IVF cycle of all patients were observed.Results The treatment group could increase the clinical pregnancy rate but had no statistical difference compared with blank control group (P>0.05). The treatment group could significantly improve the TCM syndrome score (P<0.01), reduce FSH and FSH/LH in serum (P<0.01), enhance ovarian volume and AFC (P<0.01). There was no significant effects on serum LH and uterine volume (P>0.05).Conclusion The treatment ofZishen Tiaozhou can improve the TCM syndrome score and ovarian response, and increase the clinical pregnancy rate.%目的 探讨滋肾调周法对胚胎反复移植失败(RIF)患者卵巢反应性的影响.方法 采用随机数字表,按照1:1比例将70例RIF患者分为滋肾调周治疗组和空白对照组.滋肾调周治疗组从月经第5日开始服用温肾养血颗粒,第10日改为培育颗粒,连用15 d.空白对照组不用药.3个月为1个疗程.观察患者治疗前后中医证候评分、血清卵泡刺激素(FSH)和黄体生成素(LH)水平、子宫和卵巢体积、窦卵泡计数(AFC)及进入体外受精(IVF)周期后的临床妊娠率.结果 滋肾调周治疗组可提高临床妊娠率,但与空白对照组比较差异无统计学意义(P>0.05).滋肾调周治疗组可显著改善中医证候评分(P<0.01),降低FSH、FSH/LH(P<0.01),增加卵巢体积和AFC数量(P<0.01),对LH和子宫体积无明显影响(P>0.05).结论 滋肾调周法可改善RIF患者中医证候及卵巢反应性,提高进入IVF周期后的临床妊娠率.