目的：观察天麻钩藤饮加味联合西医常规治疗早发型重度子痫前期的临床疗效。方法将60例患者随机分为治疗组和对照组各30例。2组均采用西医常规疗法,治疗组加服天麻钩藤饮加味。观察2组患者治疗前后血压、24 h尿蛋白排泄量(24 h UAE)、纤维蛋白原(FIB)、D-二聚体的变化及对妊娠结局的影响。结果治疗组在降低血压、24 h UAE、FIB、D-二聚体、妊娠并发低蛋白血症及肝肾受损方面明显优于对照组(P＜0.05)；对照组治疗前后FIB及D-二聚体无明显改变。治疗组延长孕周(15.2±4.8)d,发生新生儿窒息7例；对照组延长孕周(9.3±2.2)d,发生新生儿窒息11例。2组剖宫产率无明显差异。结论天麻钩藤饮加味联合西医常规方法治疗早发型重度子痫前期较单纯西医治疗有更好的临床疗效。%Objective To observe clinical efficacy of Tianma Gouteng Decoction combined with Western medicine for early onset severe pre-eclampsia. Methods Sixty patients were randomly divided into treatment group with 30 cases and control group with 30 cases. Two groups were both given the routine Western therapy, while the treatment group was added with Tianma Gouteng Decoction. Indicators were observed and compared between two groups including blood pressure, 24 h UAE, D-dimer, fibrinogen and their effects on pregnancy. Results Compared with the control group, the blood pressure, 24 h UAE, fibrinogen, D-dimer, hypoproteinemia, and liver and kidney function were reduced obviously in the treatment group (P<0.05);fibrinogen and D-dimer of control group were not changed significantly;gestational weeks of treatment group were extended (15.2 ± 4.8)d, and neonatal asphyxia was 7 cases;gestational weeks of control group were extended (9.3 ± 2.2)d, and neonatal asphyxia was 11 cases. There was no significant difference about cesarean section rate between the two groups. Conclusion Tianma Gouteng Decoction combined with Western medicine for treatment of early onset severe pre-eclampsia have better clinical efficacy.
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