慢性活动性肝炎细胞免疫调控中α2-巨球蛋白作用的初步探讨

摘要

The purpose of this paper is to explore the immunoregulatory effect of α2-maeroglobulin (α2M)on cellular immunity and the association of α2M purified from human plasma was capable to suppress the proliferative response of lympb ocytes to several different leetins(the effect noted was dose-dependant).T lymphocytes were found to have surface-bound α2M by the direct immunofluoresccnt technique.The serum levels of α2M were lfound elevated in 8 of the 30 CAH patients(26.7%).The proliferative response(in vitro)of lymphooytes in patients with CAH Wa S markedly increased or even restored to normal by the addition of anti-human α2M,which suggests that the function of cellular immunity of patients with CAM is closelY related to α2M.%α2-巨球蛋白(α2M)是血中具有抑制活性的免疫凋节性蛋白质.本文观察了纯化的人血清α2M对不同丝裂原刺激的淋巴细胞转化反应的影响,证实α2M具有剂量相关性抑制细胞免疫的功能.经免疫荧光技术确定了T淋巴细胞表面结合有α2M.免疫化学方法检测30例CAH患者有8例(26.7%)α2M血浓度升高,其中7例是HBsAg阳性患者.自身对照研究表明,应用特异性抗体结合α2M后,慢性活动性肝炎患者的细胞免疫功能增强,说明α2M与慢性活动性肝炎细胞免疫功能降低有密切关系