目的 验证逆行胰胆管造影(ERCP)前应用抗菌药物能否降低术后胆管炎发生率.方法 选择肝门部胆管癌需行ERCP治疗的患者138例,随机分为试验组(67例)与对照组(71例).试验组于ERCP治疗前30min静脉注射头孢哌酮1.0g;对照组按常规操作,不应用抗菌药物.结果 两组患者一般临床资料比较,差异无统计学意义(P＞0.05),具有可比性.ERCP术后,试验组胆管炎发生率为34.33％(23/67),对照组为26.76％(19/71),两组胆管炎发生率差异无统计学意义(x2=0.360,P=0.152).结论 对高感染率的病种行ERCP治疗,仅通过术前单剂量应用抗菌药物来降低ERCP治疗后胆管炎发生率,效果不甚理想.%Objective To investigate whether antimicrobial use before endoscopic retrograde cholangiopancreatog-raphy (ERCP) can decrease post-ERCP cholangitis rate. Methods 138 patients with hilar cholangiocarcinoma were randomly grouped into experimental group (67 cases) and control group(71 cases). Patients in experimental group accepted intravenous injection of cefoperazone sodium 1. 0 g 30 min before ERCP, control group were treated routinely and without using antimicrobial agents. Results There was no significant difference in general clinical data between two groups(P>0. 05). After receiving ERCP. cholangitis rate in experimental group and contro group was 34. 33% (23/67) and 26. 76%(19/71) respectively, there was no significant difference between two groups (x2 = 0. 360, P = 0.152). Conclusion Pre-ERCP antimicrobial use is not ideal for decreasing post-ERCP cholangitis rate.
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