Objective:To investigate the diagnostic and terapeutical value of FPG,GA,HbA1c and GA/HbA1c ratio in T1DM/T2DM.Methods:The study was made by case-control method.In our study,30 healthy subjects were selected from health physical ex-amination as control group while 160 diabetics were selected as case group,in which there are 76 TIDM and 84 T2DM.Analyzing the difference of relevance of FPG,GA and HbA1c,the difference of GA/HbA1c and threshold of the case and the control,and this analysis was also used between the T1DM and the T2DM.The data was managed by independent-sample t test,ROCK and Pearson correlation test of SPSS.Results:The results of FPG,GA ,HbA1c and GA/HbA1c ratio of T1DM and T2DM were significantly higher than those in the control group(P<0.01).And they were higher in the T1DM than in the T2DM(P<0.01);in the T1DM group,GA was strongly positive correlative with HbA1c(P<0.01),FPG was weakly positive correlative with GA(P>0.05),and weakly negative correlative with HbA1c(P>0.05);in T2DM group,there were positive correlation among FPG,GA and HbA1c(P<0.05),the degree of correlation ranked as HbA1c/GA>FPG/GA>FPG/HbA1c;analyzing the ROC of measures in T1DM group,the sensitivity and specificity were re-spectively 86.8% and 100% for diagnosing DM when FPG threshold was set on 5.86 mmol/L ( AUC=0.922 ) ( P<0.05 ).The sensitivity and specificity were both 100% for detecting DM when GA threshold was set on 15.5%( AUC=1 ) ( P<0.05 ).The sensitivity and specificity were respectively 98.7%and 100%for diagnosing DM when HbA1c threshold was set to 6.10%( AUC=1) ( P<0.05).The sensitivity and specificity were respectively 93.4% and 100% for diagnosing DM when the threshold of GA/HbA1c was set on 2.95 ( AUC=0.992 ) ( P<0.05 );analyzing the ROC of measures in T2DM group, the sensitivity and specificity were respectively 91.7% and 100% for diagnosing DM when FPG threshold was set on 5.94 mmol/L ( AUC=0.941 ) ( P<0.05 ).The sensitivity and specificity were respectively 85.7%and 100%for diagnosing DM when GA threshold was set on 15.5%( AUC=0.977) ( P<0.05).The sensitivity and specificity were respectively 97.6% and 100% for diagnosing DM when HbA1c threshold was set on 5.95%(AUC=0.991)(P<0.05).The ratio of GA/HbA1c had no diagnostic cutoff point,AUC was 0.644(P>0.05).Conclusion:FPG,GA, HbA1c and GA/HbA1c ratio are of high value in monitoring of blood glucose, diagnosis and typing in T1DM and T2DM.There are missed diagnosis when we diagnose T1DM and T2DM by the upper limit of reagent instruestion of FPG,GA,HbA1c.It is more important for a person with T1DM to monitor FPG than others.%目的：探讨空腹血糖（ FPG）、糖化清蛋白（ GA）、糖化血红蛋白（ HbA1c）及GA／HbA1c比值在1型糖尿病（T1DM）和2型糖尿病（T2DM）中的诊疗价值。方法：采用病例对照研究。以30例健康体检人群为正常对照组，以临床明确诊断的160例糖尿病患者为研究病例组，其中1型糖尿病（ T1DM）组为76例、2型糖尿病（ T2DM）组为84例，应用SPSS软件进行独立样本t检验、绘制受试者工作曲线（ROC曲线）及Pearson相关性检验，统计分析对照组与病例组，T1DM及T2DM组各组间FPG、GA及HbA1c的检测结果的相关性、GA／HbA1c比值及诊断切点的差异。结果：T1DM及T2DM组FPG、GA及HbA1c的检测结果及GA／HbA1c比值均明显高于对照组，且T1DM组高于T2DM组，P值均＜0.01；T1DM组中HbA1c与GA成显著性正相关（P＜0.01），FPG与GA呈弱正相关（P＞0.05）、与HbA1c呈弱负相关（P＞0.05）；T2DM组中FPG、GA及HbA1c均成正相关（P值均＜0.05），相关程度依次为HbA1c／GA＞FPG／GA＞FPG／HbA1c；评估各指标的ROC曲线分析：T1DM组中， FPG、GA、HbA1c及GA／HbA1c比值作为诊断糖尿病（DM）的切点分别为5.86 mmol／L[曲线下面积（AUC）＝0.922]、15.5％（AUC＝1.00）、6.10％（AUC＝1.00）及2.95（AUC＝0.992），其敏感性为86.8％、100％、98.7％及93.4％，特异性均为100％，P值均＜0.05；T2DM组中，FPG、GA及HbA1c作为诊断DM的切点分别为5.94 mmol／L（AUC＝0.941）、15.5％（AUC＝0.977）及5.95％（AUC＝0.991），其敏感性为91.7％、85.7％及97.6％，特异性均为100％（P值均＜0.05），GA／HbA1c比值无诊断切点（AUC＝0.644，P值＞0.05）。结论：FPG、GA、HbA1c及GA／HbA1c比值在T1DM和T2DM中具有极高的疗效观察、诊断及分型价值，应用各指标生物参考区间上限诊断T1DM和T2DM均存在漏检现象，T1DM患者密切关注FPG水平更为重要。
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