ADRB2基因rs1042713位点多态性与中国人群哮喘易感性关系的荟萃分析

摘要

目的：：应用meta分析的方法综合评价ADRB2(β-2肾上腺素能受体）基因的SNP位点[ Arg16Gly ( A46G， rs1042713）]多态性与中国人群哮喘易感性的关系。方法：检索Pubmed、Embase、Web of Knowledge、中国知网、万方、维普等数据库，收集研究ADRB2基因多态性与中国汉族人群哮喘易感性的相关文献。采用Stata12.0软件对符合纳入标准的研究做meta分析。结果：共纳入12篇文献，累计哮喘病例2193例，对照组2033例，所有入选文献均满足Hardy-Weinberg遗传平衡定律。 Meta分析结果显示，中国人群ADRB2基因rs1042713位点突变基因G携带者( GG ＋GA）的哮喘发病风险较野生型纯合子(AA）比较，总体并未显著增加(OR＝1.08，95％CI＝0.82～1.44），但亚组分析显示，G携带者儿童哮喘的发病风险相对增高(OR＝1.69，95％CI 0.99～2.87），而成人哮喘的发病风险则相对降低(OR＝0.88，95％ CI 0.68～1.15）。结论：ADRB2基因rs1042713位点基因多态性与中国儿童哮喘易感性存在一定的相关性，携带G突变基因者可相对增加儿童哮喘的患病风险。%Objective:To investigate the association between rs1042713 polymorphisms of ADRB2 gene and the susceptibility of asthma in Chinese Population by meta-analysis.Methods: The Pubmed database,Emabase database,Web of Knowledge database, CNKI database,Wanfang database and Weipu database were searched for all publications about the susceptibility of asthma and the rs1042713 polymorphisms of ADRB2 gene in Chinese Population.The article which met the inclusion criteria were assessed by the STA-TA12.0 software.Results:12 studies were included,with 2 193 asthmatic patients and 2 033 controls.All the included articles were satisfied to the Hardy-Weinberg equilibrium.The results of Meta-analysis was showed that the risk of asthma of the mutations G carriers ( GG +GA) on ADRB2 gene rs1042713 loci in Chinese people compared with the wild-type homozygotes( AA) was not significantly in-creased overall(OR=1.08,95% CI=0.82-1.44).However,subgroup analysis showed that the risk of G carriers of children had a relatively higher incidence(OR=1.69,95% CI 0.99-2.87),while the risk of adult-onset have a relatively lower incidence(OR=0.88,95%CI 0.68-1.15).Conclusion:The ADRB2 gene rs1042713 polymorphisms have a certain correlation with the susceptibility of asthma in Chinese children,the mutant gene G carriers may relatively increase the risk of asthma in childhood.