改善病情抗风湿药对类风湿关节炎患者血脂谱的影响

摘要

RA has been associated with a significantly increased risk of coronary heart disease compare to the general population because of dyslipidemia.Anti-rheumatic drugs have various effects on lipid profile,which in part appear pro-atherogenic.The aim of this review is to summarize the current knowledge on the effects of synthetic and biological disease modifying antirheumatic drugs for the treatment of RA on lipid profil,so the cardiovascular safety for antirheumatic drugs would be valuable.%类风湿关节炎(RA)患者心血管风险明显高于正常人群,血脂代谢异常与之密切相关.作为RA治疗的基石,改变病情抗风湿药(DMARDs)对血脂水平的影响仍存在很大争议,部分药物可能促进动脉粥样硬化.本文总结分析了DMARDs对RA患者血脂谱的影响,提示抗风湿药的心血管安全性应引起重视.