胸腺五肽联合HAART治疗对艾滋病患者免疫功能及生存质量的影响

摘要

Objective To investigate the effect of thymopentin combined with highly active anti-retroviral therapy (HAART) on the immune function and quality of life of patients with acquired immune deficiency syndrome(AIDS). Methods 200 AIDS patients from January 2014 to March 2017 in our hospital were randomly divided into the observation group and the control group,100 cases in each group. The control group was given HAART,and the observation group was given thymopentin combined with HAART. Both groups were treated for 24 weeks. The content of Th17 and T lymph subgroup (CD3 +, CD4 +,CD8 +) before and after treatment,levels of serum inflammatory factors (IL- 17,IL- 23),quality of life (WHOQOL-HIV-BREF) score and incidence of adverse reactions during treatment were analyzed. Results There was insignificant difference in the content of Th17,CD3 +, CD4 + and CD8 + between the two groups before treatment (P ＞ 0. 05). After treatment,the content of Th17,CD3 + and CD4 + increased,and CD8 + decreased,with statistically significant difference (P ＜ 0. 05). The content of Th17, CD3 + and CD4 + in the observation group was higher than that in the control group,and CD8 + was lower,with statistically significant differences (P ＜ 0. 05). There was insignificant difference in levels of serum IL- 17 and IL- 23 between the two groups before treatment (P ＞ 0. 05). After treatment,levels of serum IL- 17 and IL- 23 increased(P ＜ 0. 05),and those of the observation group was higher than the control group,all with statistically significant differences (P ＜ 0. 05). There was insignificant difference in the incidence of myalgia,dizziness,nausea /vomiting, chest tightness and fever between the two groups (P ＞ 0. 05). There was insignificant difference in the WHOQOLHIV-BREF scores between the two groups before treatment (P ＞ 0. 05). After treatment,the WHOQOL-HIV-BREF scores of the two groups increased (P ＜ 0. 05),and those of the observation group were higher than those of the control group,with statistically significant differences (P ＜ 0. 05). Conclusions Thymopentin combined with HAART is effective and safe in treating AIDS,which can effectively improve the immune function,reduce the inflammatory reaction and promote the reconstruction of the immune system,hereby is conducive to improving the quality of life of patients.%目的 探讨胸腺五肽联合HAART治疗对艾滋病患者免疫功能及生存质量的影响.方法选取2014年1月至2017年3月凉山彝族自治州中西医结合医院诊治的200例艾滋病患者作为研究对象.按照随机数字表法分为观察组与对照组,每组各100例.对照组给予HAART治疗,观察组给予胸腺五肽联合HAART治疗.两组均连续治疗24周.对比两组治疗前后Th17含量及T淋巴细亚群(CD3+、CD4+、CD8+)含量、血清炎性因子(IL-17、IL-23)水平、生存质量(WHOQOL-HIV-BREF评分)、治疗期间不良反应发生率.结果 两组Th17、CD3+、CD4+、CD8+含量治疗前比较差异无统计学意义(P＞0.05),治疗后两组Th17、CD3+、CD4+含量均较治疗前增加,CD8+含量较治疗前减低,差异具有统计学意义(P＜0.05),且观察组Th17、CD3+、CD4+含量高于对照组,CD8+含量低于对照组,差异具有统计学意义(P＜0.05);两组血清IL-17、IL-23水平治疗前比较差异无统计学意义(P＞0.05),治疗后两组血清IL-17、IL-23水平均较治疗前提高,差异具有统计学意义(P＜0.05),且观察组血清IL-17、IL-23水平高于对照组,差异具有统计学意义(P＜0.05);观察组肌痛、头晕、恶心/呕吐、胸闷、发热等发生率与对照组比较差异均无统计学意义(均P＞0.05);两组WHOQOL-HIV-BREF评分治疗前比较差异无统计学意义(P＞0.05),治疗后两组WHOQOLHIV-BREF评分较治疗前均有提高,差异具有统计学意义(均P＜0.05),且观察组WHOQOL-HIV-BREF评分高于对照组,差异具有统计学意义(P＜0.05).结论 HAART基础上联合胸腺五肽治疗艾滋病,可有效改善患者免疫功能、减轻机体炎性反应,促进免疫系统重建,且具有一定安全性,有利于提高患者生存质量.