精子 DNA 碎片率对女性复发性自然流产的影响

摘要

目的：探讨精子 DNA 碎片率与女性复发性自然流产的关系。方法：收集2013年6月至2013年12月在本中心就诊的发生过2次或2次以上自然流产的患者。将此配偶有不明原因复发性流产史的80例作为实验组；另外选择配偶无流产史的80例作为对照组。分别测定两组男方精子 DAN 碎片率。结果：实验组精子 DNA 碎片检出阳性32例，对照组精子 DNA 碎片检出阳性12例，有统计学差异（P ＜0.05）。结论：复发性自然流产组精子 DNA 碎片率阳性检出率显著高于对照组，提示精子 DNA 碎片率较高可能跟早期复发性自然流产有关。%Objectives:To study the influence of the rate of sperm DNA fragmentation on recurrent sponta-neous abortion.Methods:The samples of patients having had twice or more spontaneous abortion in this center from June 2013 to December 2013 were collected.The 80 patients had unexplained recurrent spontaneous abortions were selected as experimental group while the 80 ones without a history of abortion were chosen as the control group.The sperm DNA fragmentation rate of the two groups was evaluated.Results:There were 32 and 12 cases detected sperm DNA fragmentation positive in the experimental group and control group respectively,with statistically signifi-cant difference (P <0.05).Conclusions:The positive ratio of sperm DNA fragmentation in experiment group is significant higher than that of the control group.It implicates that increase in the sperm DNA fragmentation may lead to recurrent spontaneous abortion.