长期饮酒、吸烟对前列腺增生患者勃起功能及血清一氧化氮合酶与一氧化氮水平影响的研究

摘要

Objectives:To study the effect of long -term drinking and smoking on the erectile function and nitric oxide synthase and nitric oxide in patients with benign prostatic hyperplasia.Methods:120 patients with be-nign prostatic hyperplasia in our hospital were selected and divided into a long -term drinking &smoking group (60 cases)and a not long -term drinking &smoking group (60 cases).Another 60 healthy male were selected as nor-mal control group.IIEF -5 was used to investigate the subjects.Blood in the penis was taken to detect the NO con-tent and NOS activity by spectrophotometric colorimetry and nitrate reductase method.Results:The incidence of e-rectile dysfunction in both long -term drinking &smoking group and not long -term drinking &smoking group was higher than that in the control group,with statistically significant difference (P <0.05)and that of the long -term drinking &smoking group was higher than that of not long -term drinking &smoking group,with statistically signif-icant difference (P <0.05).Conclusion:Long -term drinking and smoking has great impact on the erectile func-tion of patients with prostate hyperplasia.Therefore,patients should be told to quit smoking and wine during treat-ment to enhance the curative effect.%目的：评价长期饮酒吸烟对前列腺增生患者勃起功能及血清一氧化氮合酶和一氧化氮水平影响。方法：选择来我院治疗良性前列腺增生的患者120例，分成长期饮酒吸烟组60例，不长期饮酒吸烟组60例。另选取体检健康男性60例为正常对照组。采用勃起功能国际问卷表（IIEF －5）对受试者进行调查，分别取阴茎海绵体内血液，采用硝酸还原酶法和分光光度比色法测定血浆中一氧化氮（NO）含量及一氧化氮合酶（NOS）活性。结果：长期饮酒吸烟组及不长期饮酒吸烟组勃起功能障碍发生率高于健康对照组，差异有统计学意义（P ＜0.05）。长期饮酒吸烟组勃起功能障碍高于不长期饮酒吸烟组，差异有统计学意义（P＜0.05）。结论：长期饮酒吸烟对前列腺增生患者的勃起功能影响较大，在治疗时应该嘱咐患者戒烟酒以提高疗效。