宫颈上皮内瘤变患者HPV感染情况及转阴率的相关因素分析

摘要

Objectives:To study the relative factors of human papilloma virus (HPV) infection and negative conversion ratio of cervical intraepithelial neoplasia.Methods:173 patients with cervical intraepithelial neoplasia in our hospital from January 2012 to January 2016 were selected as the research object.All patients underwent cervical intraepithelial neoplasia surgery in our hospital.Therelative influencing factors on HPV negative patients at 6 months after operation were analyzed.Results:The HPV infection rates of normal group (n =60),CIN Ⅰ (n =68),CIN Ⅱ (n =59),CIN Ⅲ (n =46) were 18.3％,63.2％ and 81.4％,respectively.Age,viral load,pathological margin,contraception,number of sexual partners and spouse sexual partner number were related to the negative rate of HPV (P ＜ 0.05).Conclusion:The infection rate of HPV increases with the degree of cervical intraepithelial neoplasia.Strict detection of HPV is beneficial to the development of early warning and improving the accuracy of cervical cancer diagnosis.Age,viral load,pathological margin,contraception,number of sexual partners andspouse sexual partners number are related factors of HPV negative rate.Controlling related factors has important significance for the prognosis of cervical intraepithelial neoplasia.%目的:研究宫颈上皮内瘤变(CIN)患者人乳头瘤病毒(HPV)感染情况及转阴率的相关影响因素.方法:选取我院2012年1月至2016年1月173例宫颈上皮内瘤患者为研究对象,进行HPV检测.所有患者均在我院接受宫颈上皮内瘤变手术治疗,对术后6个月HPV转阴的患者进行相关影响因素分析.结果:正常组(60例)、CIN Ⅰ级组(68例)、CIN Ⅱ级组(59例)、CIN Ⅲ级组(46例)的HPV感染率分别为18.3％、63.2％、81.4％、95.7％.年龄、病毒负荷量、病理切缘、避孕方式、性伴侣个数、配偶性伴侣个数等6项影响HPV转阴率的相关因素差异具有统计学意义(P＜0.05).结论:HPV感染率随宫颈上皮内瘤变病变程度增加而上升,严密检测HPV有利于预警病情发展,提高宫颈癌诊断准确率.年龄、病毒负荷量、病理切缘、避孕方式、性伴侣个数、配偶性伴侣是HPV转阴率的相关影响因素,控制相关影响因素对宫颈上皮内瘤变的预后有重要意义.