Objective To detect the expression of β-tubulin in the implantation site and the non implantation site of oviduct pregnanly and study its significance. Methods The expression of β-tubulin was detected by im-munohistochemical method. The average optical density value (AODV) of β-tubulin in epithelial tissue of the oviduct was quantitatively analyzed by image analysis system (HPIAS-1000). The AODV of β-tubulin was compared between normal secretory-phase oviduct and non-implantation site, non-implantation site and implantation site respectively. Results The positive expression of β-tubulin was lower in the non-implantation site than in normal tubal tissue at the secretory phase,and lower in the implantation site than in the non implantation site of oviduct pregnanly. The differences were significant (P<0. 05). Conclusion The lower expression of β-tubulin in the oviductal tissue may play an important role in oviductal pregnancy.%目的 探讨β-tubulin在输卵管妊娠着床部位与非着床部位的表达及其意义.方法 采用免疫组织化学方法和图像分析技术检测正常输卵管分泌期、输卵管妊娠着床部位与非着床部位β-tubulin的表达.图像分析技术检测各组输卵管粘膜上皮组织中的β-tubulin表达的平均光密度值,并分别比较正常输卵管分泌期与输卵管妊娠非着床部位、输卵管妊娠非着床部位与着床部位粘膜上皮中β-tubulin表达的差异.结果 输卵管妊娠非着床部位β-tubulin的表达弱于正常输卵管分泌期；输卵管妊娠着床部位β-tubulin的表达弱于非着床部位.差异均有显著性(P＜0.05).结论 β-tubulin的低表达可能是引起人输卵管妊娠的因素之一.
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