重症急性胰腺炎胃肠动力变化机制的研究进展

摘要

重症急性胰腺炎(SAP)胃肠动力的变化是一个临床研究较少的领域,但SAP时病人腹胀、肠麻痹等胃肠动力紊乱现象却十分常见.继发于SAP之后的胃肠动力改变的机制复杂,胃肠激素紊乱、血浆钙离子水平的下降、炎症因子大量释放、腹内高压(IAH)及腹腔间隔室综合征(ACS)、胰腺炎相关腹水(PAAF)以及SAP时的胃肠上皮细胞的凋亡改变可能是产生该现象的部分原因,探讨SAP时胃肠动力的改变机制,有利于促进对该现象的更深层次的研究,为临床治疗SAP提供理论依据.本文就SAP时病人胃肠动力变化的相关概念、机制、临床意义进行综述.%The dynamic diversity in gastrointestine of the severe aute pancreatitis (SAP) is a relatively scarce area of clinical research. During SAP, it is very common to see the phenomenon of the dynamic disorder of gastrointestine such as the paralysis of intestine, the distension of abdomen.It is complicate that the mechanisms of the dynamic diversity in gastrointestine have been secondary to the severe acute pancreatitis (SAP). It can be elucidated partly as follows: the disorder of gastrointestinal hormone, the drop of the plasma calcium levels, the release of the inflammatory factors, the formation of intra-abdominal high-pressure (IAH) and the abdominal compartment syndrome (ACS) , the pancreatitisassociated ascites fluid(PAAF) and the apoptosis of the gastrointestinal epithelial cell during SAP. To investigate the mechanism of The dynamic diversity in gastrointestine of the severe aute pancreatitis (SAP), it is beneficial to promote further research to the phenomenon and to provide a theoretical basis for the clinical treatment of SAP. The review is refered to the concept, mechanism, clinical significance of the dynamic diversity in gastrointestine during SAP.