可降解胆管修复材料的研究进展

摘要

医源性胆管损伤常用的处理方法，如胆肠吻合，由于放弃了奥狄括约肌功能，近远期有并发逆行性胆道感染、胆管炎，甚至胆管癌的风险。随着临床上对奥狄括约肌功能的重视，有必要寻找能维护胆管功能的修复材料。目前已报道的可降解胆管修复材料具有无免疫原性、暂时性支持作用、降解产物对身体无害等优点，有希望成为可供选择的胆管修复材料。本研究就可降解胆管修复材料的研究进展做一综述。%To sacrifice the function of the sphincter of Oddi in the routine management of iatrogenic biliary injury,e.g. by using cholangio-enterostomies, is often complicated by ascending biliary infection, cholangitis and an increased risk of cholangiocarcinoma. It is necessary to find a material which can protect the bile duct. As reported, biodegradable materials which are hopeful to be used clinically have the advantages of being non-immunogenic, gives temporary supportive function, and produces harmless degradation products. This article aims to review the advances in researches on biodegradable materials for bile duct repair.