深度水解蛋白配方奶对早产儿早期喂养不耐受的影响

摘要

Objective To evaluate whether extensively hydrolyzed protein formula (HPF) could improve feeding intolerance (FI) in preterm infants, compared with standard preterm infant formula (SPF). Methods 147 preterm infants admitted in neonate department in our hospital from January 2014 to December 2014. The patients were assigned into 2 groups randomly:treatment group (HPF group) and control group (SPF group). Results 147 patients were included. 71 in treatment group and 76 in control group. The weight growth was significantly greater in the treatment group than that in the control group. The rate of FI, the time of discharge of meconium and the time of establishing total enteral feeding were significantly shorter in the treatment group than those of the control group. Conclusion HPF can decease the rate of FI in preterm infants, promote discharge of meconium and weight growth.%目的：通过随机对照研究分析早期喂养深度水解配方奶（HPF）对住院早产儿喂养不耐受的改善情况。方法2014年1月-2014年12月入住新生儿科的早产儿根据入选标准纳入研究，根据是否喂养深度水解蛋白配方奶随机分为实验组（HPF组）和对照组（标准早产儿配方奶组，SPF组）。两组均开始早期微量喂养，比较两组早产儿出生2周内一般情况、喂养相关指标及其他并发症情况。结果符合入组标准完成实验的早产儿共147例，其中实验组71例，对照组76例。治疗组体重增长明显高于对照组，喂养不耐受发生率明显低于对照组，胎便排完日龄和达全奶量喂养的日龄较对照组明显缩短（P均＜0.01）。结论与标准早产儿配方奶比较，深度水解蛋白配方奶可以降低早产儿喂养不耐受的发生率，促进胎便的排出，提前达到全肠道喂养的时间。