目的 探讨高龄老年人强化降脂与心血管事件发生的相关性,以及对脑卒中患者生活质量的影响,为高龄老年人强化降脂的合理应用提供临床证据.方法 选取≥75岁高龄老年人723例,其中患有脑卒中者179例,无脑卒中者544例;降脂达标组189人,未达标组534人.收集相关病史、肝功能、血脂等指标.结果 降脂达标组发生心血管事件比例小于未达标组,差异有统计学意义(P<0.001);对于患脑卒中者,降脂达标组的改良Rankin评分(mRS)明显低于未达标组,差异有统计学意义(P=0.002).结论 高龄老年人强化降脂治疗有预防心血管事件发生的作用,且高龄老年脑卒中患者强化降脂治疗有更好的生活质量.%Objective To evaluate the relationship between low-density lipoprotein cholesterol(LDL-C)reduction therapy and major adverse cardiovascular events(MACE;myocardial infarction,stroke and vascular death)in elderly patients,to assess the effect of LDL-C reduction therapy in patients with stroke on life quality and to obtain clinical evidence of LDL-C reduction therapy in elderly patients. Methods A total of 723 patients over the age of 75 years old were selected for the study. The patients were divided into two groups, patients with stroke (n=179)or non-stroke patients (n=544),and were also subdivided into two groups:reached the LDL-C goal of 1.80 mmol/L (n=189) and unreached LDL-C goal (n=534). Their serum levels of LDL-C were measured,and their levels of alanine aminotransferase(ALT) were tested. Results The rate of occurred MACE was lower in patients who reached the LDL-C goal than the unreached patients (P < 0.001). In the group with stroke,neurological function (mRS)was better in the reached group compared with the unreached (P=0.002). Conclusion LDL-C reduction therapy in elderly patients is effective and can improve the life quality in patients with stroke.
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