肉桂水提液对全脑缺血再灌注损伤大鼠羟自由基和谷胱甘肽过氧化物酶的影响

摘要

目的 探讨肉桂水提液对全腩缺血再灌注损伤大鼠羟自由基(·OH)和谷胱甘肽过氧化物酶(GSH-Px)活性的影响.方法 采用4-血管阻断(4-VO)方法建立全脑缺血再灌注动物模型,利用分光光度法测定大鼠脑、肝、肾、心等组织中·OH抑制能力和GSH-PX活性的变化.结果 与模型组相比,各剂量给药组大鼠各组织中·OH的抑制能力和谷胱甘肽过氧化物酶(GSH-PX)的活性明显提高(P<0.01或P<0.05).结论 肉桂水提液可预防性降低自由基代谢造成的机体损伤,提高GSH-Px的活性,对脑缺血再灌注损伤具有保护作用.%Objective To study the effects of aqueous extract of cinnamon on ? OH and GSH-Px in the whole cerebral ischemia reperfusion injury rats. Methods Model of cerebral ischemia reperfusion injury was established by four-vessel occlusion (4-VO). The inhibited ability of ? OH and the activity of GSH-Px in the brain,heart,liver,kidney tissues were determined by the Ultraviolet Spectrophotome-ter. Results Compared with the cerebral ischemia reperfusion group,aqueous extract of cinnamon could decrease ? OH (P <0.01 or P < 0.05) , and enhance the activity of GSH-Px remarkably (P < 0. 01 or P < 0.05). Conclusions Aqueous extract of cinnamon could enhance the activities of GSH-Px,scavenge ? OH. It is a good scavenger of free radicals and had good anti-oxidation effects.