牙周炎、血脂异常与超敏C-反应蛋白的关系

摘要

目的 通过分析牙周炎患者的血脂指标和超敏C-反应蛋白(hs-CRP)水平,探讨牙周炎、血脂异常和hs-CRP之间的相互关系.方法 体检中心体检人群中随机纳入6 190人,年龄在20～89岁.按年龄分组分为:20～40岁组、41～65岁组、≥66岁组;按是否患牙周炎分为:牙周炎组和非牙周炎组;按是否合并血脂异常分为对照组、单纯血脂异常组、单纯牙周炎组和牙周炎+血脂异常组.对所有调查对象均进行总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、脂蛋白a(lpa)和hs-CRP检测.结果 与非牙周炎组比较,男性或20～40岁组的牙周炎患者hs-CRP三个水平段(1～3 mg/L、3～10 mg/L和>10 mg/L)的构成比明显升高,而41～65岁组牙周炎患者仅1～3 mg/L和3～10 mg/L两个水平段构成比升高.与单纯血脂异常组比较,单纯牙周炎组TG、LDL-C、lpa和hs-CRP水平明显降低,而牙周炎+血脂异常组TC、TG、LDL-C、LDL-C、lpa和hs-CRP水平明显升高,HDL-C水平则明显降低.结论 牙周炎与血循环中hs-CRP水平升高相关,而牙周炎合并血脂异常患者的血脂水平和hs-CRP水平较单纯血脂异常者或牙周炎患者高.因此,在治疗牙周炎的同时,积极预防血脂异常能有效的降低心血管疾病的患病风险.%Objective To analyze the lipid and high sensitive C-reactive protein (hs-CRP) levels in patients with periodontitis and investigate the relationship among periodontitis, dyslipidemia and hs-CRP. Methods 6 190 sample were selected, aged 20 ～ 89 years.Subjects were divided into 3 groups by age: 20 ～ 40, 41 ～ 65, and ≥ 66 years old groups. By whether with periodontal disease, subjects were divided into periodontitis and non-periodontitis groups; by whether with dyslipidemia into control, dyslipidemia, periodontitis, dyslipidemia and periodontitis groups. Total cholesterol (TC), triglyeeride (TG), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C), lipoprotein a (lpa) and hs-CRP were measured. Results Compared to non-periodontitis group, there were three proportions in 20 ～ 40 years old group or male groups at 1 ～3, 3 ～ 10 and ＞ 10 mg/L hs-CRP was significantly higher (P ＜0. 05). Only proportions at 1 ～ 3 mg/L and 3 ～ 10 mg/L were higher (P ＜0. 05) in 41 ～ 65 years old group. Compared to the dyslipidemia group, TG, LDL-C, lpa and hs-CRP levels were significantly lower in periodontitisgroup (P ＜ 0. 05 ); TC, TG, LDL-C, lpa and hs-CRP of levels were significantly higher, HDL-C level was significantly lower in dyslipidemiaand periodontitis groups (P ＜ 0.05 ). Conclusions Periodontitis can induce high level hs-CRP, the lipid level and the hs-CRP level are significantly higher in dyslipidemia and periodontitis. Therefore, dyslipidemia should be prevented to reduce the risk of cardiovascular disease during treating periodontitis.