绝经后冠心病患者血浆雌二醇与心室重构及NT-proBNP的相关性

摘要

Objective To investigate the relationships of estradiol with NT-proBNP, left ventricular end diastolic diameter (LVEDd) and left ventricular mass index(LVMI) in postmenopausal women with coronary heart disease (CHD).Methods 50 CHD patients and 40 control subjects were selected from Nanfang Hospital .The levels of estradiol and NT-proBNP were examined .So were levels of LVEDd and LVMI.Basic clinical data were evaluated,including age,hypertension,body surface area(BSA),and body mass index(BMI).Results Compared with those of control subjects,NT-proBNP,LVEDd,LVMI were elevated and estradiol was decreased (P<0.05) in CHD group. There was not significant difference in age ,hypertension,BSA,BMI between two groups.There was negative correlation between NT-proBNP, LVEDd,LVMI and estradiol.Conclusions Postmenopausal women with CHD have lower level of estradiol ,which appears to be associated with greater left ventricular remodeling and higher level of NT-proBNP.%目的：探讨绝经后冠心病妇女血浆雌二醇与左心室重构及N末端脑钠尿肽前体（ NT-proBNP）水平的关系。方法选择绝经期女性90例，其中冠心病组50例，非冠心病对照组40例，收集年龄、血压、体表面积、体重指数等基本信息，均检测血浆雌二醇、NT-proBNP 水平，测定左心室舒张末期内径、左心室质量指数。结果冠心病组与对照组年龄、血压水平、体表面积、体重指数比较均无统计学差异（ P＞0.05）。冠心病组与对照组相比，血浆雌二醇显著降低，NT-proBNP、左心室舒张末期内径、左心室质量指数显著增加（ P＜0.05）。 Pearson直线相关分析表明，冠心病组血浆雌二醇与NT-proBNP（r＝－0.565，P＜0.05）、左心室舒张末期径（r＝－0.731，P＜0.05）、左心室质量指数（r＝－0.768，P＜0.05）呈显著负相关。结论绝经后冠心病患者血浆雌二醇水平下降，但NT-proBNP、左心室舒张末期内径、左心室质量指数增加；雌二醇水平与 NT-proBNP、左心室舒张末期内径、左心室质量指数呈负相关。