非编码RNA在白色脂肪组织棕色化中的研究进展

摘要

机体内储存脂类的白色脂肪可在生理或药物条件刺激下,具有产热及能量消耗增加的棕色脂肪样功能,生成米色脂肪.白色脂肪组织棕色化能调节能量代谢稳态,可作为治疗肥胖症和代谢综合征等疾病的潜在靶点.影响白色脂肪组织棕色化的因素众多,其中具有调控功能的非编码RNA在该过程起重要作用.本文就近年非编码RNA在白色脂肪组织棕色化中的研究进展进行综述.%White fat with lipids storage in the body can be stimulated by physiological or medical conditions to have the brown fat-like functions of an increased heat production and a high-energy consumption,becoming a beige fat.The browning of white fat can be used as a potential target for the treatment of diseases such as obesity and metabolic syndrome.There are many factors,such as non-coding RNA (ncRNA),can promote the browning of white fat,with the resulting energy metabolism homeostasis of brown fat function.This paper reviews recent advances on the study of ncRNAs promoting the browning of white fat.