老年肿瘤患者血清促红细胞生成素变化及其与化疗的关系

摘要

目的 分析老年肿瘤患者血清促红细胞生成素(Epo)水平及其与血红蛋白(Hb)的关系,以及化疗对其的影响. 方法 应用ELISA方法 检测老年肿瘤患者血清Epo,并观察化疗后Epo变化. 结果 (1)老年组Epo为(22.0±15.1)U/L,与对照组(30.4±21.8)U/L比较,差异无统计学意义(t=1.2988,P＞0.05);Epo水平与Hb水平存在负相关关系(r=0.3700,P＜0.01);(2)55例Hb正常者Epo为(14.7±10.6)U/L,22例轻度贫血者(20.2±9.O)U/L,23例中重度贫血者(42.3±24.8)U/L,差异有统计学意义(F=11.6886,P＜0.01);(3)化疗4周期和2周期后,贫血组Epo分别为(45.2±39.1)U/L和(25.8±15.9)U/L,与治疗前的(20.2±10.8)U/L比较,差异有统计学意义(F=4.5477,PG0.01);Hb分别为(96.8±16.6)g/L和(102.1±19.3)g/L,与治疗前的(111.0±20.5)g/L比较,差异有统计学意义(F=4.0071,PG0.01). 结论 老年肿瘤患者与非老年肿瘤患者比较,Epo水平差异无统计学意义;贫血患者Epo水平明显高于无贫血患者;Epo水平与Hb值呈负相关关系;化疗可以引起部分患者发生贫血,并且随着化疗周期的增加,Hb值下降而Epo水平升高.%Objective To study the relationship between serum erythropoietin(Epo)level and chemotherapy-induced hemoglobin(Hb)level in elderly patients with cancer. Methods　One hundred senile patients(aged≥60 years)with cancer and one hundred and seventy non-senile patients(aged＜60 years)with cancer were selected as aged group and control group,respectively.The serum Epo level was detected by enzyme-linked immunosorbent assay(ELISA). Results　(1)The average levels of the serum Epo in aged group and control group were(22.0±15.1)U/L and(30.4±21.8)U/L,respectively(t=1.2988,P＞0.05).A negative correlation was found between the levels of Epo and Hb in elder cancer patients(r=0.3700,P＜0.001).(2)The levels of serum Epo were(14.7±10.6)U/L,(20.2±9.0)U/L and(42.3±24.8)U/L in 55 cases with normal Hb level,22 cases with mild anemia and 23 cases with moderate to severe anemia,respectively(F=11.6886,P＜0.01).(3)The levels of Epo were(20.2±10.8)U/L,(45.2±39.1)U/L and(25.8±15.9)U/L before chemotherapy,after 4 treatment cycles and 2 treatment cycles respectively(F=4.5477,P＜0.01).The levels of Hb were(111.0±20.5)g/L,(96.8±16.6)g/L and(102.1±19.3)g/L before chemotherapy,after 4 treatment cycles and 2 treatment cycles respectively(F=4.0071,P＜0.01).Conelusions　There is no statistical difference in serum Epo level between senile patients with cancer and non-senile patients with cancer.but serum Epo levelis higher in patients with anemia than without anemia.There is a negative correlation between the levels of Epo and Hb.Chemotherapy can decrease the level of Hb and increase the serum 1evel of Epo in part of patients.The changes are correlated with the conditions of patients before chemotherapy and the time of chemotherapy.