骨钙素与老年2型糖尿病的相关性研究

摘要

Objective To investigate the correlation between serum osteocalcin and type 2 diabetes mellitus (T2DM) in elderly patients.Methods A total of 55 T2DM patients (diabetic group) and 50 non-diabetic subjects (control group) aged ≥60 years were enrolled in this study.The levels of fasting blood glucose (FBG),glycated hemoglobin (HbAlc),insulin resistance index (HOMA IR),osteocalcin (OC),body mass index (BMI) and bone mineral density (BMD) in groups were compared.The correlations between serum osteocalcin and the above indicators were analyzed.Results The levels of OC and BMD were higher in control group than in diabetic group [(11.2±3.2)μg/Lvs.(4.1±3.0)μg/L,(-1.3±0.3) vs.(-2.6±0.5),respectively,both P＜0.05].The levels of FBG,HbAlc,FINS,HOMA-IR were lower in control group than in diabetic group [(4.7±2.0) mmol/L vs.(9.4±2.1) mmol/L],[(4.8±1.5) ％ vs.(7.6±1.6)％,(7.4±3.2) U/L vs.(23.7±3.0) U/L,(1.5±0.7) vs.(9.9±1.2),respectively,all P＜0.05].Serum osteocalcin concentration was negatively correlated with the levels of FBG,HbAlc,FINS and HOMA-IR in elderly patients with T2DM (r=-0.739,-0.713,-0.613,-0.092,all P＜0.01).Conclusions Serum osteocalcin concentration is correlated with the levels of blood sugar and insulin resistance index in elderly patients with T2DM.A further study on the correlation between osteocalcin and T2DM may provide a new target for the treatment of type 2 diabetes mellitus.%目的 研究老年2型糖尿病患者血糖、胰岛素、胰岛素抵抗指数、骨密度与骨钙素的相关性. 方法 选择55例2型糖尿病患者和50例非糖尿病对照者,年龄均≥60岁,比较两组间的空腹血糖(FBG)、糖化血红蛋白(HbAlc)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、骨钙素、体质指数(BMI),骨密度,分析血清骨钙素水平与各项指标的相关性. 结果 对照组的骨钙素[(11.2±3.2) μg/L比(4.1±3.0)μg/L]、骨密度(-1.3±0.3比-2.6±0.5)高于老年2型糖尿病组,空腹血糖[(4.7±2.0) mmol/L比(9.4±2.1) mmol/L]、糖化血红蛋白[(4.8±1.5)％比(7.6±1.6)％]、胰岛素[(7.4±3.2) U/L比(23.7±3.0) U/L]、胰岛素抵抗指数(1.5±0.7比9.9±1.2)低于老年2型糖尿病组(P＜0.05).骨钙素与老年2型糖尿病患者的FBG、HbAlc、FINS、HOMA-IR呈负相关(r=-0.739、-0.713、-0.613、-0.092,均P＜0.05),骨钙素与骨密度呈正相关(r=0.269,P＜0.05). 结论 血清骨钙素水平与老年2型糖尿病患者的血糖水平及胰岛素抵抗程度相关.