抗抑郁治疗对老年良性前列腺增生合并抑郁患者的影响

摘要

Objective To explore the influence of antidepression therapy on symptom score and quality of life in elderly benign prostatic hyperplasia with depression.Methods A total of 94 elderly patients with benign prostatic hyperplasia and depression were randomly divided into two groups:control group (regular drugs) and therapy group adding citalopram 20 mg,once daily for 3 months.The changes of internatio nal prostate sympeom score (IPSS) symptom score,hamilton depression (HAMD) and scores of short form (36) health survey before and after treatment were compared between the two group.Results After treatment,IPSS symptom score [(10.74 ± 4.72) vs.(16.42±8.09)] was much lower in therapy group than in control group (t=4.16,P＜0.05).Each dimension of quality of life was increased after antidepression treatment [physical function (67.75 ± 9.99) vs.(63.09±7.90),SF-36 role physical (70.90±10.85) vs.(62.81±9.16),bodily pain indices (72.75± 10.59) vs.(63.13 ± 9.47),general health (62.59 ± 9.38) vs.(53.67 ± 7.52),vitality (64.09±8.96) vs.(58.11 ± 7.87),social functioning (71.84 ± 6.87) vs.(64.99 ± 7.21),roleemotional (70.15±9.93) vs.(65.01±9.18),mental health (68.74±8.23) vs.(61.77±7.83),all P＜0.05].Conclusions More attention should be paid to antidepression therapy in the elderly with benign prostatic hyperplasia and depression.%目的 了解抗抑郁治疗对老年良性前列腺增生(BPH)合并抑郁患者症状评分和生活质量的影响. 方法 选取2008年8月至2012年5月在我院内科住院的老年BPH合并抑郁患者94例进行调查,随机分为对照组和治疗组各47例,对照组给予常规药物治疗,治疗组在常规药物治疗基础上加用抗抑郁治疗西酞普兰20 mg,1次/d,服用3个月,比较两组治疗前后国际前列腺症状评分(IPSS)、抑郁量表评分和SF-36量表评分的变化. 结果 与对照组相比,治疗组治疗后的IPSS评分明显降低[(10.74±4.72)分比(16.42±8.09)分],差异有统计学意义(t=4.16,P＜0.01)；生活质量各维度均升高,生理功能、生理机能、躯体疼痛、总体健康、活力、社会功能、情感职能、心理健康治疗组分别为(67.75±9.99)分、(70.90±10.85)分、(72.75±10.59)分、(62.59±9.38)分、(64.09±8.96)分、(71.84±6.87)分、(70.15±9.93)分、(68.74±8.23)分,对照组分别为(63.09±7.90)分、(62.81±9.16)分、(63.13±9.47)分、(53.67±7.52)分、(58.11±7.87)分、(64.99±7.21)分、(65.01±9.18)分、(61.77±7.83)分(t=2.51、3.91、4.64、5.09、3.44、4.72、2.61、4.21,均P＜0.05). 结论 老年BPH合并抑郁患者在药物治疗BPH的同时要重视抗抑郁治疗.