胱抑素C与老年人高血压靶器官损害的关系

摘要

Objective To investigate correlation between cystatin C (Cys C) and target organ damage (TOD) in elderly hypertension and its clinical significance.Methods One hundred patients with TOD in elderly hypertension were selected as an observation group.One hundred patients without TOD in elderly hypertension were recruited as the controll group.And sixty healthy aged persons were recruited as healthy group.Serum concentration of Cys C in all cases was measured by the particle enhanced nephelometric immunoassay.At the same time,serum creatinine (Scr),urine albumin (mALB) and left ventricle mass index (LVMI) via ultrasonography were also detected.Correlation of Cys C with the above measurements were analyzed.Results The Cys C concentration was significantly higher in observation group [(1.84±0.32) mg/L] than in contrast [(0.92±0.36) mg/L] and healtbygroups [(0.85±0.34) mg/L],F=88.43,P=0.000.However,the difference in level of Cys C was not statistically significantly different between controll group and healthy group (P ＞0.05).In observation group,serum concentration of Cys C was positively correlated with Scr,mALBand LVMI (r=0.420,0.526,0.470,P=0.021,0.019,0.034) after adjusting age.Conclusions Serum level of Cys C is markedly elevated and is positively correlated with Scr,mALB and LVMI in patients with TOD in elderly hypertension.It can be considered as one of the useful factors for evaluating TOD in elderly hypertension.%目的 探讨胱抑素C(Cys C)与老年人高血压靶器官损害的相关性及临床意义. 方法 选择老年高血压伴靶器官损害(TOD)的患者100例作为观察组,老年高血压不伴TOD患者100例为对照组,同时选取60例健康老年人作为健康老年组,抽取空腹静脉血采用免疫比浊法测定各组患者的Cys C水平,同时检测血肌酐、尿微量白蛋白(mALB),超声波图像评估左心室质量指数(LVMI),分析Cys C与各项指标的相关性. 结果 观察组、对照组和健康老年组Cys C水平分别为(1.84±0.32) mg/L、(0.92±0.36) mg/L和(0.85±0.34) mg/L,观察组Cys C水平明显高于对照组和健康老年组(F=88.43,P=0.000),而对照组和健康老年组Cys C水平差异无统计学意义(P＞0.05).经偏回归分析剔除年龄因素后,观察组患者血清Cys C水平与血肌酐、尿mALB、LVMI呈正相关(r=0.420、0.526、0.470,P=0.021、0.019、0.034). 结论 老年高血压靶器官损害患者血清Cys C水平明显升高,并与血肌酐、尿mALB及LVMI呈正相关,血清Cys C水平可作为评估老年高血压患者靶器官损害的指标之一.