尼麦角林治疗非痴呆型血管性认知功能障碍的疗效观察

摘要

目的 观察尼麦角林对非痴呆型血管性认知功能障碍(VCIND)患者的认知及执行功能的影响. 方法 68例VCIND患者分为尼麦角林组和对照组,尼麦角林组35例,口服尼麦角林10 mg,3次/d,连续用12周;对照组33例,仅行常规治疗用药前后均行认知及执行功能评定. 结果 与对照组相比尼麦角林组用药后词语即刻回忆、数字符号转换测验、词语流畅性测验、画钟表测验以及简易智力状态测查的成绩提高(P＜0.05). 结论 尼麦角林对非痴呆型血管性认知功能障碍患者的注意力,记忆力有一定改善作用,患者总体的认知功能也有一定的提高.%Objective To investigate the effect of nicergoline on cognitive ability and executive function for patients with vascular cognitive impairment without dementia (VCIND).Methods Totally 68 patients with VCIND were divided into conventional treatment group (33 cases) and nicergoline treatment group (35 cases,nicergoline 10 mg,tid added on basal conventional treatment).All of cases were continuously treated for 12 weeks.Cognitive ability and executive function before and after treatments were evaluated.Results Test scores of immediate free recall of a list of words,the numbers and symbols transformation,the word fluency,clocks and watches painting,and minimental state examination (MMSE) were significantly higher in nicergoline treatment group than in conventional treatment group (P＜0.05).Conclusions Nicergoline may improve attention and memory as well as cognitive ability in patients with vascular cognitive impairment without dementia.