Objective To observe influence of Ergot Lin on executive function and cognitive function of patients with vascular cognitive impairment no dementia(VCIND) .Methods A total of 82 cases of patients with VCIND from January to December in 2015 in People′s Hospital of Liaoning Province were recruited into this study ,and randomly divided into two groups by using hidden Numbers ,each group with 41 cases .The treatment such as depressurization ,expansion of cerebral artery ,anticoagulant ,lowering the level of blood glucose and lipid were conducted 12 weeks in the two groups ,and Ergot Lin was given only in the observation group .Executive function ,cognitive function cognitive function ,mental state and daily life ability were evaluated and compared in the two groups after receiving treatment for 6 months .Results After receiving treatment 6 months ,the classification score of exec-utive ability in observation group was greater than that at admission ,error response and persistent error were less than those on ad-mission(P<0 .05) ,however there were no significant differences on these three factors score between that after treatment and at admission in the control group(P>0 .05) .There were significant differences on the three factors score between observation group and control group after treatment(P<0 .05) .Scores of Simple Intelligence Scale Mental State Examination (MMSE) ,Ability to Dai-ly Life Scale(ADL) ,Montreal Cognitive Assessment(MOCA) after treatment were significant higher than those on admission in ob-servation group(P<0 .05) .However ,only MMSE score after treatment in the control group was better than that at admission (P<0 .05) ,no statistical significant differences were found on MOCA ,ADL scores after treatment and that at admission in control group (P>0 .05) .MOCA ,MMSE ,ADL scores in observation group after treatment were higher than those in the control group (P<0 .05) .No obvious adverse reactions were found in the two groups .Conclusion Ergot Lin with VCIND could improve execution and cognitive function ,mental state and daily life ability ,meanwhile it is safe and reliable .%目的 观察尼麦角林对非痴呆型血管性认知功能障碍(VCIND)患者执行和认知功能的影响.方法 选择该院2015年1-12月住院的VCIND患者82例,采用隐匿数字随机法分为2组,每组41例,入院后均给予降压、扩张脑动脉、抗凝、降糖、调脂等治疗12周;观察组患者在此基础上给予尼麦角林治疗12周;比较2组入院时、疗程结束后6个月执行功能、认知功能、精神状态及日常生活能力.结果 疗程结束后6个月,观察组执行能力方面完成分类数大于入院时,错误应答数和持续性错误数少于入院时,差异有统计学意义(P<0.05);对照组完成分类数、错误应答数、持续性错误数与入院时比较,差异均无统计学意义(P>0.05).观察组治疗后完成分类数、错误应答数、持续性错误数与对照组比较,差异均有统计学意义(P<0.05).认知功能精神状态及日常生活能力方面,观察组治疗后简易精神状态检查量表(MMSE)、日常生活能力量表(ADL)和蒙特利尔认知评估量表(MOCA)评分明显高于入院时(P<0.05);对照组治疗后MMSE评分明显高于入院时(P<0.05);MOCA、ADL评分与入院时比较,差异无统计学意义(P>0.05).观察组治疗后MOCA、MMSE、ADL评分均高于对照组,差异有统计学意义(P<0.05).2组患者治疗期间未发现明显不良反应病例.结论 尼麦角林可提高VCIND患者的执行和认知功能,同时对患者精神状态和日常生活能力的提高也有明显的作用,而且安全、可靠.
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