退行性心脏瓣膜病患者血清微小RNA-222和白细胞介素6水平变化及其临床意义

摘要

Objective To study the serum miRNA-222 and IL-6 levels and their clinical significance in degenerative heart valvular disease (DHVD) patients.Methods One hundred DHVD patients admitted to our hospital from January 2016 to November 2016 were divided into single DHVD group (n=48) and multiple DHVD group (n=52) with 30 DHVD free subjects undergoing physical examination served as a control group in this study.Their serum miRNA-222 and IL-6 levels were measured and the association between their serum miRNA-222 and IL-6 levels was analyzed.Results The serum miRNA-222 and IL-6 levels were significantly higher in single DHVD group and multiple DHVD group than in control group (0.136±0.013 vs 0.029±0.005,0.205±0.018 vs 0.029±0.005,P＜0.01;3.814±0.108 ng/L vs 2.351±0.116 ng/L,4.479±0.104 ng/L vs 2.351±0.116 ng/L,P＜0.01) and in multiple DHVD group than in single DHVD group (P＜0.01).The serum miRNA-222 level was positively associated with the serum IL-6 level in DHVD patients (r=0.586,P＜0.01).Conclusion Serum miRNA-222 and IL-6 levels are involved in the development and progression of DHVD.%目的 探讨退行性心脏瓣膜病患者血清微小RNA-222(miR-222)、白细胞介素6(interleukin-6,IL-6)水平变化及其临床意义.方法 选择2016年1～11月徐州医科大学附属淮安医院老年科住院的退行性心脏瓣膜病患者100例,其中单瓣膜病变组48例,多瓣膜病变组52例;健康体检者30例作为对照组.比较3组血清miR-222和IL-6水平.直线相关性分析退行性心脏瓣膜病患者血清miR-222与IL-6的相关性.结果 单瓣膜病变组和多瓣膜病变组血清miR-222和IL-6水平明显高于对照组[0.136±0.013、0.205±0.018 vs 0.029±0.005,(3.814±0.108)ng/L、(4.479±0.104)ng/L vs (2.351±0.116)ng/L,P＜0.01],且多瓣膜病变组血清miR-222和IL-6水平明显高于单瓣膜病变组,差异有统计学意义(P＜0.01).退行性心脏瓣膜病患者血清miR-222与IL-6呈正相关(r=0.586,P＜0.01).结论 血清miR-222和IL-6可能参与了退行性心脏瓣膜病的发生、发展.