大动脉粥样硬化型脑梗死患者侧脑室旁白质疏松的影响因素研究

摘要

Objective To study the risk factors for periventricular hyperintensity (PVH) in patients with large artery atherosclerotic ischemic stroke by analyzing its incidence.Methods Two hundred and seventy-three patients with large artery atherosclerotic ischemic stroke were divided into PVH-free group (n=102),mild PVH group (n=100) and severe PVH group (n=71).Their rick factors for vascular diseases,location of large artery stenosis,lesion of bilateral artery,and type of ischemic stroke were compared.Results The sex,age,and history of hypertension and ischemic stroke differed greatly in 3 groups (P＜0.05,P＜0.01).Age and hypertension were the independent risk factors for PVH (OR=1.112,OR=2.992,P=0.000) and were positively related with PVH.The longer the disease course was,the severer the PVH was in 45-64 years old patients.Conclusion The location of intracranial/extracranial stenosis is not a risk facor for PVH.Vascular rick factors play a major role in the development and progression of PVH in patients with large artery atherosclerotic ischemic stroke.%目的 分析大动脉粥样硬化型脑梗死患者侧脑室旁白质疏松(PVH)的发病情况,探索在犬动脉粥样硬化型脑梗死患者中PVH的影响因素.方法 回顾性分析273例大动脉粥样硬化型脑梗死患者,按照有无PVH分为无病变组102例,轻度组100例和中重度组71例,比较各组间的血管危险因素、大血管狭窄部位、是否双侧病变及梗死类型.结果 3组患者的性别、年龄、高血压及脑卒中比较,差异有统计学意义(P＜0.05,P＜0.01).年龄及高血压是PVH的独立危险因素(OR=1.112,OR=2.992,P=0.000).高血压分级及起病年龄与PVH病变程度呈正相关;中年起病患者中,病程越长,PVH越重.结论 颅内外血管狭窄部位并非PVH的影响因素,大动脉粥样硬化型脑梗死患者中PVH的发生及进展仍主要受血管危险因素的影响.