局部亚低温对急性脑梗死氧自由基及炎症反应的干预作用

摘要

收集2008年7月至2010年6月的45例急性脑梗死患者,随机分为亚低温治疗组21例和对照组24例,对照组给予常规抗血小板等治疗,亚低温组在常规治疗基础上给予病灶侧局部亚低温治疗24 h.结果显示,与对照组相比,治疗组第14,30天美国国立卫生研究院卒中量表(NIHSS)评分明显降低(P＜0.05),第7,14天血中神经元特异性烯醇化酶、一氧化氮(NO)、白细胞介素-6和细胞问黏附分子-1含量明显降低,超氧化物歧化酶活力明显升高(P＜0.05).局部亚低温治疗可减轻急性脑梗死的炎症反应,减少自由基产生.%Forty five patients with acute cerebral infarction were randomized to two groups: in treatment group patients received local subhypothermia and conventional therapy, in control group patients received conventional therapy only. Clinical outcome was assessed by the National Institutes of Health Stroke Scale (NIHSS) on admission and at 7, 14 and 30 d after treatment. Serum neuron specific enolase (NSE), nitrogen monoxide ( NO ) , superoxide dismutase (SOD), interleukin-6 (IL-6 ) and intercellular adhesion molecule-1 (ICAM-1) were detected on admission and at 7,14 d after treatment The study showed that NIHSS scores of treatment group on 14, 30 d were lower than those of control group ( P ＜ 0. 05 ). Serum NSE, NO, IL-6 and ICAM-1 levels significantly decrease; while serum SOD levels increased (P ＜ 0. 05). In conclusion, local subhypothermia therapy can inhibit inflammatory reaction, reduce oxygen free radical formation and improve neurological function in patients with acute cerebral infarction.