PDZ结合域转录共激活因子在结肠癌组织中的表达及其临床意义

摘要

Objective To investigate the expression of transcriptional coactivator with PDZ-binding motif (TAZ) in colon cancer tissues and its association with clinicopathological parameters and prognosis of patients.Methods The expression of TAZ protein was detected in 56 resected colon cancer tissues and matched tumor-adjacent tissues using immunohistochemistry.The positive expression rate of TAZ was compared between patients with different clinicopathological features.The association between TAZ expression and prognosis was analyzed.Results Expression of TAZ protein located in the nucleolus.The positive expression rate of TAZ in colon cancer tissues was significantly higher than that in matched tumor-adjacent tissues (73.2％ vs.12.5％, P=0.000).Clinicopathological evaluation suggested that the expression of TAZ protein was associated with tumor size (P=0.009), depth of infiltration (P=0.026), lymph node metastasis (P=0.007) and TNM staging (P=0.004).Colon cancer patients with negative expression of TAZ showed a better 5-year survival as compared with those with positive expression of TAZ (66.7％ vs.22.9％, P=0.0017).Multivariate Cox regression analysis revealed that positive TAZ expression was an independent factor for predicting poor prognosis in colon cancer (HR:3.532, 95％ CI: 1.3-9.9, P=0.016).Conclusion The expression of TAZ protein is up-regulated in colon cancer tissues and its high expression is associated with poor prognosis of colon cancer patients.%目的 探讨结肠癌组织中PDZ结合域转录共激活因子(TAZ蛋白)的表达及其与患者临床病理特征及预后的关系.方法 采用免疫组织化学法检测56例结肠癌及对应癌旁组织中TAZ蛋白表达情况,比较不同病理特征患者TAZ的阳性表达率,并分析其表达与结肠癌患者生存预后的关系.结果 TAZ蛋白表达主要定位于细胞核,其在结肠癌组织中的阳性率明显高于对应癌旁组织[73.2％(41/56)比12.5％(7/56),P=0.000].TAZ蛋白在结肠癌组织中的表达与肿瘤大小(P=0.009)、浸润深度(P=0.026)、淋巴结转移(P=0.034)和TNM分期(P=0.002)有关.TAZ阴性表达患者5年生存率明显高于阳性表达患者(66.7％比22.9％,P=0.0017).多因素回归分析显示,TAZ蛋白阳性表达是影响患者预后的独立因素[HR(95％CI):3.532(1.266～9.858),P=0.016].结论 TAZ蛋白在结肠癌组织中的表达异常升高,且与结肠癌患者不良预后相关.