Background:Abnormal immune response is involved in the pathogenesis of Crohn’s disease( CD),and T lymphocytes are the main players in the immune response. Aims:To investigate the relationship between peripheral blood CD3 + ,CD4 + and CD8 + T cells and inflammation-related markers in patients with CD. Methods:Proportions of peripheral blood CD3 + ,CD4 + and CD8 + T cells were measured by flow cytometry in 26 CD patients( including 14 patients in active stage and 12 in remission stage )and 8 healthy volunteers(control group),and their correlation with inflammation-related markers(including white blood cell count,platelet count,ESR,CRP,albumin and hemoglobin) were analyzed. Results:Proportions of CD3 + ,CD4 + and CD8 + T cells were significantly increased in patients with active CD than those with remission CD and controls( P ﹤ 0. 05),however,no significant differences were found between remission CD patients and controls(P ﹥ 0. 05). ESR and CRP in active CD patients were significantly higher than those in controls(P ﹤ 0. 05),while albumin and hemoglobin levels were significantly decreased(P ﹤ 0. 05);albumin in remission CD patients was significantly lower than that in controls(P ﹤ 0. 05). No significant differences in white blood cell count and platelet count were found between active,remission CD patients and controls(P ﹥ 0. 05). Proportions of CD3 + , CD4 + and CD8 + T cells were positively correlated with CRP,and negatively correlated with hemoglobin( P ﹤ 0. 05);CD3 + and CD4 + T cells were positively correlated with ESR(P ﹤ 0. 05). However,CD3 + ,CD4 + and CD8 + T cells were not correlated with white blood cell count,platelet count and albumin level( P ﹥ 0. 05). Conclusions:Proportions of peripheral blood CD3 + ,CD4 + and CD8 + T cells are increased with the increase of disease activity in CD,and are positively correlated with CRP,and negatively correlated with hemoglobin.%背景：克罗恩病（CD）的发病机制与机体免疫应答异常有关，T 细胞参与机体免疫应答过程。目的：研究 CD 患者外周血 CD3＋、CD4＋、CD8＋ T 细胞变化与炎症相关指标的关系。方法：应用流式细胞仪检测26例 CD 患者（活动期14例和缓解期12例）和8名健康志愿者（对照组）外周血 CD3＋、CD4＋、CD8＋ T 细胞比例，并分析与炎症相关指标（白细胞计数、血小板计数、ESR、CRP、白蛋白和血红蛋白）的相关性。结果：CD 活动期 CD3＋、CD4＋、CD8＋ T 细胞比例均明显高于缓解期和对照组（P ﹤0.05），但缓解期与对照组间差异无统计学意义（ P ﹥0.05）。CD 活动期ESR 和 CRP 明显高于对照组（P ﹤0.05），血红蛋白和白蛋白水平明显低于对照组（P ﹤0.05），CD 缓解期白蛋白水平明显低于对照组（P ﹤0.05），而 CD 活动期和缓解期白细胞计数、血小板计数与对照组相比差异均无统计学意义（P ﹥0.05）。CD3＋、CD4＋和 CD8＋ T 细胞比例与 CRP 呈正相关、与血红蛋白呈负相关（P ﹤0.05），CD3＋、CD4＋ T 细胞比例与 ESR 呈正相关（P ﹤0.05）；CD3＋、CD4＋和 CD8＋ T 细胞比例与白细胞、血小板计数和白蛋白均无关（P ﹥0.05）。结论：CD 患者 CD3＋、CD4＋和 CD8＋ T 细胞比例随病情活动而升高，并与 CRP 呈正相关，与血红蛋白呈负相关。
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