Hp根除的影响因素分析和双歧杆菌对再根除的影响

摘要

背景:幽门螺杆菌(Hp)对抗菌药物的耐药率逐年增加,导致根除率降低,寻找有效的Hp根除方案迫在眉睫.目的:分析不同因素对Hp根除率的影响,并探讨双歧杆菌对Hp再根除的效果.方法:选取经胃镜和病理检查确诊且Hp阳性的203例胃部疾病患者,予标准三联抗菌治疗2周,停药4周后复查Hp.将50例根除失败患者分为2组,对照组患者给予四联疗法,实验组患者在此基础上预先口服双歧杆菌.分析性别、年龄、胃镜诊断、病理诊断、不同根除方案对Hp根除率的影响,并评估双歧杆菌对Hp再根除的影响.结果:男女患者之间Hp根除率无明显差异(P =0.740),Hp根除率随年龄增加呈下降的趋势,但差异无统计学意义(P =0.872).不同根除疗法、胃镜诊断和病理诊断对Hp根除率均无明显差异(P＞0.05).双歧杆菌组的Hp再根除率较对照组有所升高,但差异无统计学意义(88.0％对72.0％,P=0.289).结论:性别、年龄、不同根除方案、胃镜诊断和病理诊断对Hp的根除率均无明显影响,但Hp根除率随年龄增加呈下降的趋势,慢性萎缩性胃炎的Hp根除率相对较高,双歧杆菌并不能明显提高初次Hp根除失败者的再根除率.%Background:Antibiotic resistance rate of Helicobacter pylori (Hp) has increased year by year,which leads to the lowering Hp eradication rate,therefore,it is emergent to find an effective Hp eradication regimen.Aims:To explore the effect of influencing factors on Hp eradication rate,and to investigate the clinical effect of Bifidobacterium on re-eradication of Hp.Methods:A total of 203 Hp-positive patients with gastric diseases diagnosed by gastroscopy and pathology were enrolled.All the patients were given standard triple regimen for 2 weeks,Hp infection was re-examined 4 weeks after treatment.Fifty patients with Hp eradication failure were divided into two groups,patients in experimental group were given Bifidobacterium followed by quadruple therapy,patients in control group were given quadruple therapy directly.Effects of gender,age,gastroscopic diagnosis,pathological diagnosis and different regimens on Hp eradication rate were analyzed,and effect of Bifidobacterium on re-eradication of Hp was evaluated.Results:No significant difference in Hp eradication rate was found between male and female patients (P =0.740).Hp eradication rate decreased with the increase of age,however,the difference was not statistically significant (P =0.872).No significant differences in Hp eradication rate were found between different eradication regimens,gastroscopic diagnosis,and pathological diagnosis (P ＞ 0.05).Reeradication rate of Hp in Bifidobacterium group was higher than that in control group,but the difference was not statistically significant (88.0％ vs.72.0％,P =0.289).Conclusions:The effects of gender,age,gastroscopic diagnosis and pathological diagnosis,different eradication regimens on Hp eradication rate are not statistically different.However,Hp eradication rate is decreased with the increase of age.Hp eradication rate is relatively high in patients with chronic atrophic gastritis.Bifidobacterium can not increase the re-eradication rate in patients with the failure of first time Hp eradication therapy.