多聚糖止血粉在上消化道内镜黏膜下剥离术中的应用及其与凝血酶冻干粉预防再出血的对比

摘要

Objective To investigate the clinical effect of polysaccharide hemospheres on hemostasis and preventing rehaemorrhagia in upper gastrointestinal endoscopic submucosal dissection ( ESD) . Methods Sixty-seven hospitalized patients who underwent ESD for upper gastrointestinal tract mucosal lesions were selected. Among them, 32 cases still had bleeding wounds after regular treatment, and they were treated with polysaccharide hemospheres. Thirty-five cases had clear wounds and used lyophilizing thrombin powder to prevent rehaemorrhagia. Time of hemostasis and the success rate of hemostasis were observed in polysaccharide hemospheres. After 30 days of follow-up, the safety was observed. Results In the 32 patients treatment with polysaccharide hemospheres, the average dosage during operation was (1. 97 ± 1.04)g, the average hemostasis time was (83.81 ±59.94)s, and the success rate of hemostasis was 96.88%. There were no significant differences in hemoglobin, platelet count, prothrombin time, INR, partial thromboplastin time and thrombin time in patients with preoperative and postoperative (P>0. 05). After the operation, no rehaemorrhagia was found in polysaccharide hemospheres group, but 4 cases of rehaemorrhagia were found in lyophilizing thrombin powder group, the difference was statistically significant (P0. 05).术后多聚糖止血粉组患者均未发生再出血,凝血酶冻干粉组有4例发生不同程度的再出血,差异有统计学意义(P<0. 05).结论 上消化道ESD中使用多聚糖止血粉效果显著、安全.与凝血酶冻干粉相比,可显著降低术后再出血风险.