肝硬化晚期严重并发症包括难治性腹水、自发性腹膜炎、肝肾综综合征(HRS)等.国外文献报道肝硬化并发腹腔积液患者1年的肝肾综合征发生率为18％,5年为40％.在肝功能衰竭患者中,肝肾综合征发生率为60％～80％.一旦发生肝肾综合征,治疗相当困难,肝移植是唯一有效的根治方法.肝肾综合征预后差,3个月病死率高达80％～100％.其中肝肾综合征Ⅰ型的预后更差,若无干预治疗,中位生存期不足2周.所以肝肾综合征早期诊断对诊疗方案调整、药物剂量调整及预后评估有重要意义.%Refractory ascites, spontaneous bacterial peritonitis and hepatorenal syndrome are severe complications of advanced cirrhosis. The probabilities of HRS occurrence among cirrhotic patients with ascites at 1 and 5 years have been reported to be 18% , 40% respectively, and 60% -80% with liver failure. HRS is associated with a poor prognosis and a high mortality rate within 3 months up to 80% ~ 100%. The only effective treatment is liver transplantation. The median survival in patients developing to HRS type I is <2 weeks without therapeutic intervention. Therefore, early recog-nization of HRS has great significance in treatment management and prognosis.
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