Cyr61和HIF-1α在胃癌中的表达及临床意义

摘要

Objective To detect the expression of Cyr61 and HIF-lα in gastric cancer, and analyze correlation of Cyr61 and HIF-1α with invasion and metastasis of gastric cancer. Methods The inmuohistochemistry was used to detect the expression of Cyr61 and HIF-1 α in specimens from 40 patients with gastric cancer, 40 paired adjacent gastric cancer (2 cm from the carcinoma) , and 40 surgical nargins of paired normal gastric tissues (5 cm from the carcinoma). The correlation of Cyr61 and HIF-1α with clinicopathologic characteristics of gastric cancer was analyzed. Results The expression of Cyr61 was 95％ in cancer tissues. It was significantly higher than that in the paired adjacent gastric cancer (80％) and normal gastric tissues (50％) (P ＜0. 01 ). The expression of HIF-1α was 90％ in gastric cancer tissues. It was significantly higher than that in the paired adjacent gastric cancer (35％) and normal gastric tissues (2.5％) (P ＜0.01 ). The increased expression of Cyr61 and HIF-1α were closely associated with the degree of differentiation, lymph node metastasis and TNM staging of gastric cancer (P ＜ 0.05). Conclusion The expression of Cyr61 and HIF-1α were significantly highest in gastric cancer. At the same time, the increased expression of Cyr61 and HIF1α protein may promote the invasion and metastasis of gastric cancer.%目的 研究Cyr61和HIF-1α在胃癌、癌旁和正常组织中的表达水平,并探讨二者与胃癌侵袭转移的关系.方法 将标本分成3组,分别为40例胃癌组、40例配对的癌旁组(距癌2 cm)和40例配对的正常组(距癌5 cm以上),免疫组织化学方法检测Cyr61和HIF-1α的表达水平,并分析二者与胃癌的临床病理特征的关系.结果 Cyr61在胃癌中的表达率(95%)高于癌旁组(80%)和正常组(50%),差异均有统计学意义(P均＜0.01).HIF-1α在胃癌中的表达率(90%)高于癌旁组(35%)和正常组(2.5%),差异均有统计学意义(P均＜0.01).Cyr61和HIF-1α表达的增强与肿瘤的分化程度、淋巴转移及TNM分期相关(P均＜0.05).结论 Cyr61和HIF-1α蛋白在胃癌组织中呈高表达,可能与胃癌的侵袭转移相关.