扬州地区408例肝硬化病因分析

摘要

目的 探讨扬州地区肝硬化患者的病因特点.方法 回顾性分析2005年1月-2011年12月在本院住院的408例肝硬化患者的病因.结果 乙型肝炎病毒感染所致肝硬化167例(40.9%),血吸虫性肝硬化56例(13.7%),酒精性肝硬化55例(13.5%),丙型肝炎病毒感染所致肝硬化50例(12.3%),酒精合并肝炎病毒共同损伤所致肝硬化25例(6.1%),血吸虫合并肝炎病毒共同损伤所致肝硬化21例(5.1%),隐源性肝硬化24例(5.9%),其他10例(2.5%).7年间酒精性肝硬化患者人数构成比明显增加(P<0.05),而肝炎后肝硬化患者人数构成比明显降低(P<0.05).混合因素所致肝硬化Child C级患者比例明显高于单病因所致肝硬化患者(43.5% vs 22.3%,P<0.05).结论 扬州地区肝硬化病因仍以乙型病毒性肝炎为主,而酒精性肝硬化呈上升趋势.混合病因所致肝硬化患者病情较单病因肝硬化患者重.%Objective To investigate the characteristics of the cause of liver cirrhotic patients in Yangzhou. Methods Etiology of cirrhosis from Jan. 2005 to Dec. 2011 during our hospital in 408 patients was analyzed retrospectively. Results 167 cases (40. 9% ) were caused by the infection of hepatitis B virus, while 56 cases (13.7%) by schistoso-miasis infection, 55 cases(13.5% ) by alcoholic taking hepatitis, 50 patients (12.3% ) by the infection of hepatitis C virus, 25 cases (6. 1% ) by alcoholic and hepatitis virus common injury, 21 cases (5. 1% ) by schistosomiasis and hepatitis virus common injury, 24 cases (5.9% ) by cryptogenic cirrhosis, and there were other 10 cases (2.5% ). The number of patients with alcoholic cirrhosis significantly increased (P <0. 05) , while the number of patients with cirrhosis after hepatitis significantly decreased (P <0.05) in the seven years. Mixing factors due to liver cirrhosis Child class C patients was significantly higher than that due to a single cause of liver cirrhosis patients (43. 5% vs 22.2)% , P < 0.05). Conclusion Cause of cirrhosis of the conclusion of Yangzhou region is still mainly viral hepatitis B, alcoholic cirrhosis of the liver upward trend. Mixed etiology in patients with cirrhosis due to liver cirrhosis patients' condition was more serious than the single cause.