随着时间的变迁,幽门螺杆菌(Helicobacter pylori,H.pylori)对常用抗生素的耐药率逐渐增加,其根除率逐渐下降.四联疗法已成为当前治疗H.pylori的主要一线方案,另外欧州MaastrichtⅣ共识意见中还推荐了序贯疗法和伴同疗法.在H.pylori对常用抗生素耐药的情况下,对于如何提高H.pylori根除率,我国H.pylori学者正在进行H.pylori治疗新路径探索:(1)三联(或四联)联合中药治疗；(2)三联(或四联)联合益生菌治疗；(3)探索口腔H.pylori对H.pylori根除治疗的影响；(4)强调个体化治疗.今天的新思路也许会成为明天治疗H.pylori的新手段.%The eradication rate of H. pylori infection has decreased as the resistance to antibiotics of H. pylori had increased gradually in recent years. Quadruple regimen has been considered as the main first line treatment strategy. The consequence and concomitant therapies were recommended by Europe Maastricht IV Consensus. There are 4 methods which we hope to be the new treatment strategies: ( 1) triple/quadruple regimen + Chinese traditional medicine; (2 ) triple/quadruple regimen + probiotics; (3) to investigate the effect of H. pylori in oral cavity on the eradication of H. pylori infection; (4) individual therapy. These new attempt might become the new strategy in the future.
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