抗幽门螺旋杆菌治疗对慢性乙型肝炎临床疗效的影响

摘要

目的 探讨幽门螺旋杆菌(He1icobacter pylori,H.pylori)感染对慢性乙型肝炎(CHB)患者消化道症状(包括食欲不振、恶心、腹胀、乏力)及肝功能(包括血清总胆红素、谷丙转氨酶、胆碱酯酶、凝血酶原时间、血清白蛋白)相关指标的影响.方法 对82例CHB伴有H.pylori感染的患者,分别检测其肝功能,将轻、中度慢性乙型肝炎患者分别随机1∶1分配,构成治疗组和对照组各41例,在保肝对症治疗基础上,治疗组给予埃索美拉唑镁肠溶片、阿莫西林、克拉霉素三联抗H.pylori治疗10天,同时每周检测一次肝功能,连续5次,进行相关分析.结果 抗H.pylori治疗后,两组消化道症状与肝功能比较有显著性差异.结论 H.pylori治疗有利于明显改善慢性乙型肝炎伴有H.pylori感染患者临床症状、肝功能及可能预后.%Objective To explore the influence of Helicobacter pylori (H. pylori) on the gastric symptoms ( poor appetite, nausea, bloating and fatigue) and liver functions of patients with chronic hepatitis B (CHB). Methods 82 CHB patients detected with H. pylori infection were recruited in the study. The patients whose liver function were severely damaged were excluded, so the 82 patients were the ones whose liver functions were slightly and moderately damaged. The 82 patients were assigned into experimental and control groups matching their liver functions. Both groups accepted general liver function enhancement treatment. In addition, the experimental group was provided with anti-H. pylori medications, which included esomeprazole magnesium, amoxicillin and clarithromycin. The treatment lasted for 10 days. Liver functions were tested to both groups every week for five weeks. Results Significant differences were found between the two groups, with fewer symptoms and better liver functions in the experimental group. Conclusion The anti-H. pylori treatment can reduce the gastric symptoms of the CHB patients and improve their liver functions. The treatment has the potential to improve prognosis of the CHB patients.