结肠癌血行转移患者的凝血功能变化

摘要

Objective To investigate the changes of blood coagulation function in colon cancer with hematogenous metastasis. Methods One hundred and thirty-nine cases of colon cancer patients from Nov. 2011 to Oct. 2013 in Renmin Hospital of Wuhan University were collected, including 28 patients with distant metastasis of colon cancer which including 19 cases of hematogenous metastasis,and 30 patients with benign diseases of colon, retrospective analysis of conventional indicators of coagulation before the treatment. Results Compared with the control group, the platelet ( PLT) level and fibrinogen ( Fbg) level in colon cancer group were increased, and prothrombin time ( PT) was pro-longed (P<0. 05). Among the groups, the plasma thrombin time (TT) had no significant difference (P>0. 05). The levels of activated partial thromboplastin time ( APTT) in the hematogenous metastasis patients were shortened signifi-cantly, and the levels of D-dimer were increased, compared with the control group and non-metastasis group, there were significant differences ( P<0 . 05 ) . Conclusion The abnormal blood coagulation indicators may be the important influ-ence factors of colon cancer hematogenous metastasis. To actively improve the hypercoagulability of colon cancer patients can not only reduce the patients with thrombosis, but also affect the colon tumor growth and metastasis, so as to prolong the survival of patients.%目的：探讨结肠癌血行转移患者凝血功能的变化。方法收集武汉大学人民医院2011年11月-2013年10月确诊的139例结肠癌患者(包括结肠癌远处转移患者28例，其中19例为血行转移)与同期住院的30例结肠良性疾病患者病例资料，回顾性分析治疗前凝血常规指标。结果与对照组比较，结肠癌组血小板( PLT)水平、纤维蛋白原( Fbg)水平升高，凝血酶原时间( PT)延长，差异均有统计学意义(P<0.05)；各组间血浆凝血酶时间(TT)水平相比，差异无统计学意义(P>0.05)；血行转移组活化部分凝血活酶时间(APTT)、D-二聚体(D-Dimer)水平升高，与对照组及无转移组相比，差异有统计学意义(P<0.05)。结论凝血指标的异常可能是血行转移的重要影响因素。积极改善患者血液高凝状态不仅可以减少血栓形成，还可以影响结肠肿瘤的生长和转移，从而延长患者的生存期。