氧气吸入是治疗一些疾病的重要手段,尤其可改善新生儿缺氧状态。但长时间的高氧治疗会对机体器官产生严重的毒性作用。高氧能诱发线粒体产生活性氧( reactive oxygen species,ROS)进而引起器官损伤。高氧环境中肠上皮细胞遭到破坏时伴随着ROS的增加,激活NF-κB信号通路,进而引起一系列的炎症反应,因此,ROS在高氧肠道损伤中发挥着重要作用。%Oxygen is an important way for the treatment of some diseases, especially to improve newborn hypoxia state.But high oxygen treatment for a long time could have serious toxic effect on the body’ s organs.Hyperoxia can in-duce mitochondria produce reactive oxygen species( ROS) and cause organ damage.Hyperoxia’ s environment in intesti-nal epithelial cells were destroyed along with the increase of ROS, activity of the NF-κB signaling pathways, resulting in a series of inflammation, thus ROS plays an important role in hyperoxia intestinal injury.
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