急性药物性肝损伤患者肝脏硬度值测定及其影响因素分析

摘要

Objective To analyze the change of liver stiffness measurement ( LSM) and its related factors in patients with acute drug induced liver injury ( DILI) . Methods Thirty DILI patients were collected. A set of blood biochemical indicators were defined and tested, LSM was measured by liver transient elastography ( Fibroscan,FS) . Indicators were re-tested after 2~6 weeks' regular treatment, and the multiple correlation analysis was used to explore the influence factors of LSM. Results LSM was significant differences before and after treatment (P<0. 05). Changes of TBIL and PTA were related with the change of LSM (P<0. 05). Multiple regression analysis suggested the levels of TBIL and LSM were posi-tively correlated. Conclusion LSM values in patients with acute DILI are downtrend with the disease better. TBIL possi-bly influences LSM during FibroScan test.%目的 分析急性药物性肝损伤(drug induced liver injury,DILI)患者治疗前后肝脏硬度测量值(liver stiffness measurement,LSM)的变化及其相关影响因素.方法 急性DILI患者30例,入院后完善肝功能等检测指标,并通过肝脏瞬时弹性超声(Fi-broScan,FS)测定其LSM,常规治疗2~6周后再次复查上述各项观察指标,通过多元相关分析探讨LSM的影响因素.结果 30例急性DILI患者治疗前后LSM差异有统计学意义(P=0.013);治疗前后检测TBIL、PTA的变化值与LSM变化量之间有相关性(P<0.05);多元回归分析显示TBIL水平与LSM呈正相关.结论 急性DILI患者的LSM随疾病好转呈下降趋势,TBIL会对LSM产生影响.