非酒精性脂肪性肝病与心脏左室结构和功能变化相关性的临床研究

摘要

目的 探讨非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)与心脏左室结构和功能变化的相关性.方法 将研究对象分为NAFLD组(223例)和对照组(259例),超声测定心脏左室舒张末期直径、室间隔厚度、左室后壁厚度、左室射血分数、E峰值、A峰值,并计算其左室质量指数、相对室壁厚度、E/A值.结果 NAFLD组左室质量指数、相对室壁厚度高于对照组(P＜0.05),E/A值低于对照组(P＜0.05),射血分数与对照组相比,差异无统计学意义(P＞0.05).相对室壁厚度增大、左室舒张功能受限与NAFLD明显相关(P＜0.05),校正性别、年龄、吸烟、高血压、糖尿病、BMI等因素后,仍具有相关性(P＜0.05).结论 NAFLD与心脏相对室壁厚度增大、左室舒张功能受限显著相关.%Objective To investigate the correlation of non-alcoholic fatty liver disease (NAFLD) with the changes of left ventricular structure and function in the heart.Methods The subjects were divided into NAFLD group and control group based on their liver ultrasound results.The left ventricular end-diastolic diameter,interventricular septum thickness,posterior wall thickness,ejection fraction,E peak,A peak were determined,and the left ventricular mass index,relative wall thickness,E/A value were measured and recorded.Results Compared with control group,the left ventricular mass index,relative wall thickness were higher,while the value of E/A was lower in NAFLD group (P ＜0.05).There was no significant difference in ejection fraction between two groups (P ＞ 0.05).Increase of relative wall thickness,left ventricular diastolic dysfunction were associated with NAFLD (P ＜ 0.05).When adjusted for gender,age,smoking,hypertension,diabetes,BMI and other factors,the correlations were still existed (P ＜0.05).Conclusion NAFLD is significantly related to the increase of ventricular wall thickness and left ventricular diastolic dys function.