不同数量13C-UBT检测值与幽门螺杆菌根除率的关系及影响因素

摘要

目的 探讨不同数量13C-UBT检测值与幽门螺杆菌(Helicobacter pylori,H.pylori)根除率的关系及影响因素.方法 收集2016年1月至2016年8月新疆维吾尔自治区人民医院消化科门诊患者中13 C-UBT检测结果阳性并行胃黏膜组织病理切片检查者634例,分析不同数量13C-UBT检测值与H.pylori根除率的关系及影响因素.结果 不同数量13C-UBT检测值的H.pylori根除率随13C-UBT检测值的增加而降低(90.0％、89.7％、85.0％、77.2％),onetile组根除率较quartile组根除率高,且差异有统计学意义(90.0％ vs 77.2％,P=0.029).H.pylori根除率与不同数量13C-UBT检测值相关.H.pylori密度与十二指肠溃疡、胃黏膜糜烂、13C-UBT检测值、胃黏膜萎缩、肠化相关.结论 不同数量13C-UBT检测值与H.pylori根除率相关,十二指肠溃疡、胃黏膜糜烂、胃黏膜萎缩、肠化及13C-UBT检测值可能影响H.pylori密度的程度.%Objective To explore the relationship between Helicobacter pylori (H.pylori) eradication rate and the different numbers of 13C-UBT and its influencing factors.Methods From Jan.2016 to Aug.2016 in the People's Hospital of Xinjiang Uygur Autonomous Region,634 patients whose results of 13C-UBT test were positive and underwent gastric mucosal biopsy were detected.The relationship between the 13C-UBT detection value and H.pylori eradication rate,and the influencing factors were analyzed.Results The eradication rates of H.pylori with different amounts of 13C-UBT were decreased (90.0％,89.7％,85.0％,77.2％).The eradication rate in the onetile group was higher than that in the quartile group,and there was significance difference (90.0％ vs 77.2％,P=0.029).H.pylori eradication rate was correlated with different 13C-UBT values.H.pylori density was associated with duodenal ulcer,gastric mucosal erosion,13C-UBT detection value,gastric mucosal atrophy and intestinal metaplasia.Conclusion The detection value of 13C-UBT is correlated with the H.pylori eradication rate,duodenal ulcer,gastric mucosal erosion,gastric mucosal atrophy,intestinal metaplasia and 13C-UBT detection values may affect the degree of H.pylori density.